Evidence map›Paper›PMID 34164059›Full record

ArticleChemical science2021

Discovery and biosynthesis of guanipiperazine from a NRPS-like pathway.

Jing Shi, Xiang Xu, Pei Yi Liu, Yi Ling Hu, Bo Zhang, Rui Hua Jiao, Ghader Bashiri, Ren Xiang Tan, Hui Ming Ge

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. AApplied and environmental microbiology · 2024
    Article
  7. Article
  8. Bacterial natural product discovery by heterologous expression.Journal of industrial microbiology & biotechnology · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Modulating Complex Secondary Metabolism inFood technology and biotechnology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 4 countries.

Jing ShiState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Institute of Artificial Intelligence Biomedicine, Nanjing University Nanjing 210023 China rxtan@nju.edu.cn hmge@nju.edu.cn.
Xiang XuState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Institute of Artificial Intelligence Biomedicine, Nanjing University Nanjing 210023 China rxtan@nju.edu.cn hmge@nju.edu.cn.
Pei Yi LiuState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Institute of Artificial Intelligence Biomedicine, Nanjing University Nanjing 210023 China rxtan@nju.edu.cn hmge@nju.edu.cn.
Yi Ling HuState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Institute of Artificial Intelligence Biomedicine, Nanjing University Nanjing 210023 China rxtan@nju.edu.cn hmge@nju.edu.cn.
Bo ZhangState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Institute of Artificial Intelligence Biomedicine, Nanjing University Nanjing 210023 China rxtan@nju.edu.cn hmge@nju.edu.cn.
Rui Hua JiaoState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Institute of Artificial Intelligence Biomedicine, Nanjing University Nanjing 210023 China rxtan@nju.edu.cn hmge@nju.edu.cn.
Ghader BashiriLaboratory of Structural Biology, Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland Auckland 1010 New Zealand.
Ren Xiang TanState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Institute of Artificial Intelligence Biomedicine, Nanjing University Nanjing 210023 China rxtan@nju.edu.cn hmge@nju.edu.cn.
Hui Ming GeState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Institute of Artificial Intelligence Biomedicine, Nanjing University Nanjing 210023 China rxtan@nju.edu.cn hmge@nju.edu.cn.ORCID https://orcid.org/0000-0002-0468-808X
Institute of Art · PLUniversity of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonribosomal peptide synthetases (NRPSs) are modular enzymes that use a thiotemplate mechanism to assemble the peptide backbones of structurally diverse and biologically active natural products in bacteria and fungi. Unlike these canonical multi-modular NRPSs, single-module NRPS-like enzymes, which lack the key condensation (C) domain, are rare in bacteria, and have been largely unexplored to date. Here, we report the discovery of a gene cluster (

Identifiers

PMID34164059
PMCPMC8179380
OpenAlexW3118639736

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.