Evidence map›Paper›PMID 34164050›Full record

ArticleChemical science2020

An explicitly designed paratope of amyloid-β prevents neuronal apoptosis

Ashim Paul, Sourav Kumar, Sujan Kalita, Sourav Kalita, Dibakar Sarkar, Anirban Bhunia, Anupam Bandyopadhyay, Amal Chandra Mondal, Bhubaneswar Mandal

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ashim PaulLaboratory of Peptide and Amyloid Research, Department of Chemistry, Indian Institute of Technology Guwahati (IITG) North Guwahati Assam-781039 India bmandal@iitg.ac.in.ORCID https://orcid.org/0000-0003-2182-8248
Sourav KumarNeuroscience Research Unit, Department of Physiology, Raja Peary Mohan College Hooghly Uttarpara West Bengal-712258 India acmondal@mail.jnu.ac.in.
Sujan KalitaLaboratory of Peptide and Amyloid Research, Department of Chemistry, Indian Institute of Technology Guwahati (IITG) North Guwahati Assam-781039 India bmandal@iitg.ac.in.
Sourav KalitaLaboratory of Peptide and Amyloid Research, Department of Chemistry, Indian Institute of Technology Guwahati (IITG) North Guwahati Assam-781039 India bmandal@iitg.ac.in.
Dibakar SarkarBiomolecular NMR and Drug Design Laboratory, Department of Biophysics, Bose Institute P-1/12 CIT Scheme VII (M) Kolkata 700054 India.
Anirban BhuniaBiomolecular NMR and Drug Design Laboratory, Department of Biophysics, Bose Institute P-1/12 CIT Scheme VII (M) Kolkata 700054 India.ORCID https://orcid.org/0000-0002-8752-2842
Anupam BandyopadhyayPeptide Engineering Laboratory, Department of Chemistry, Indian Institute of Technology Ropar Punjab-140001 India.ORCID https://orcid.org/0000-0002-3221-0315
Amal Chandra MondalNeuroscience Research Unit, Department of Physiology, Raja Peary Mohan College Hooghly Uttarpara West Bengal-712258 India acmondal@mail.jnu.ac.in.ORCID https://orcid.org/0000-0003-0491-7804
Bhubaneswar MandalLaboratory of Peptide and Amyloid Research, Department of Chemistry, Indian Institute of Technology Guwahati (IITG) North Guwahati Assam-781039 India bmandal@iitg.ac.in.ORCID https://orcid.org/0000-0003-3435-5443
Indian Institute of Technology Guwahati · INBose Institute · INIndian Institute of Technology Ropar · INJawaharlal Nehru University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic antibodies hold great promise in combating diseases, diagnosis, and a wide range of biomedical applications. However, designing a therapeutically amenable, synthetic antibody that can arrest the aggregation of amyloid-β (Aβ) remains challenging. Here, we report a flexible, hairpin-like synthetic paratope (

Identifiers

PMID34164050
PMCPMC8179358
OpenAlexW3113484671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.