Evidence map›Paper›PMID 34164030›Full record

ArticleChemical science2020

Single-molecule fluorescence detection of a tricyclic nucleoside analogue.

George N Samaan, Mckenzie K Wyllie, Julian M Cizmic, Lisa-Maria Needham, David Nobis, Katrina Ngo, Susan Andersen, Steven W Magennis, Steven F Lee, Byron W Purse

Abstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Single-Molecule Stoichiometry of Supramolecular Complexes.Journal of the American Chemical Society · 2024
    Article
  8. 1Molecules (Basel, Switzerland) · 2024
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

George N SamaanDepartment of Chemistry and Biochemistry and the Viral Information Institute, San Diego State University San Diego CA 92182 USA bpurse@sdsu.edu.
Mckenzie K WyllieDepartment of Chemistry and Biochemistry and the Viral Information Institute, San Diego State University San Diego CA 92182 USA bpurse@sdsu.edu.
Julian M CizmicDepartment of Chemistry and Biochemistry and the Viral Information Institute, San Diego State University San Diego CA 92182 USA bpurse@sdsu.edu.ORCID https://orcid.org/0000-0003-3202-3138
Lisa-Maria NeedhamUniversity of Cambridge, Chemistry Department Lensfield Road Cambridge CB2 1EW UK.ORCID https://orcid.org/0000-0002-8139-5862
David NobisSchool of Chemistry, University of Glasgow University Avenue Glasgow G12 8QQ UK.ORCID https://orcid.org/0000-0003-4853-8881
Katrina NgoDepartment of Chemistry and Biochemistry and the Viral Information Institute, San Diego State University San Diego CA 92182 USA bpurse@sdsu.edu.
Susan AndersenDepartment of Chemistry and Biochemistry and the Viral Information Institute, San Diego State University San Diego CA 92182 USA bpurse@sdsu.edu.
Steven W MagennisSchool of Chemistry, University of Glasgow University Avenue Glasgow G12 8QQ UK.ORCID https://orcid.org/0000-0002-4327-8366
Steven F LeeUniversity of Cambridge, Chemistry Department Lensfield Road Cambridge CB2 1EW UK.ORCID https://orcid.org/0000-0003-4492-5139
Byron W PurseDepartment of Chemistry and Biochemistry and the Viral Information Institute, San Diego State University San Diego CA 92182 USA bpurse@sdsu.edu.ORCID https://orcid.org/0000-0002-0052-6067

Funding

THE INTERSECTION OF LANGUAGE AND AFFECTR25GM058906 · NIGMS · SAN DIEGO STATE UNIVERSITY · PI TONG, WILLIAM G. · 1999 to 2021
$10.7M
NIGMS NIH HHS R25 GM058906
6 · The paper itself

Abstract

Fluorescent nucleobase surrogates capable of Watson-Crick hydrogen bonding are essential probes of nucleic acid structure and dynamics, but their limited brightness and short absorption and emission wavelengths have rendered them unsuitable for single-molecule detection. Aiming to improve on these properties, we designed a new tricyclic pyrimidine nucleoside analogue with a push-pull conjugated system and synthesized it in seven sequential steps. The resulting

Identifiers

PMID34164030
PMCPMC8179283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.