Evidence map›Paper›PMID 34163891›Full record

ArticleChemical science2020

Enhancing glycan stability

Alexander Axer, Ravindra P Jumde, Sebastian Adam, Andreas Faust, Michael Schäfers, Manfred Fobker, Jesko Koehnke, Anna K H Hirsch, Ryan Gilmour

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Direct Regioselective para-Fluorination via I(I)/I(III) Catalysis.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Rapid and Reliable Conformational Analysis of Glycans by Small Angle X-Ray Scattering Guided Molecular Dynamics Simulations.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025
    Article
  7. Article
  8. Expediting Glycospace Exploration: Therapeutic Glycans via Automated Synthesis.Angewandte Chemie (International ed. in English) · 2025
    Review
  9. Article
  10. A Fluorinated Sialic Acid Vaccine Lead Against Meningitis B and C.Journal of the American Chemical Society · 2024
    Article
  11. Fluorinated ManJournal of the American Chemical Society · 2023
    Article
  12. Fluorinated carbohydrates forChemical Society reviews · 2023
    Review
  13. Fluorine-Directed Automated Mannoside Assembly.Angewandte Chemie (International ed. in English) · 2023
    Article
  14. Synthetic Approaches to Break the Chemical Shift Degeneracy of Glycans.Chembiochem : a European journal of chemical biology · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Alexander AxerOrganisch Chemisches Institut, WWU Münster Corrensstraße 36 48149 Münster Germany.
Ravindra P JumdeDepartment of Drug Discovery and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) University Campus E8.1 66123 Saarbrücken Germany.ORCID https://orcid.org/0000-0002-2674-9605
Sebastian AdamWorkgroup Structural Biology of Biosynthetic Enzymes, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Institute for Infection Research (HZI) University Campus E8.1 66123 Saarbrücken Germany.ORCID https://orcid.org/0000-0003-3319-6356
Andreas FaustEuropean Institute for Molecular Imaging Münster Germany.
Michael SchäfersEuropean Institute for Molecular Imaging Münster Germany.
Manfred FobkerCenter for Laboratory Medicine, WWU Münster Münster Germany.
Jesko KoehnkeWorkgroup Structural Biology of Biosynthetic Enzymes, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Institute for Infection Research (HZI) University Campus E8.1 66123 Saarbrücken Germany.ORCID https://orcid.org/0000-0002-7153-1365
Anna K H HirschDepartment of Drug Discovery and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI) University Campus E8.1 66123 Saarbrücken Germany.ORCID https://orcid.org/0000-0001-8734-4663
Ryan GilmourOrganisch Chemisches Institut, WWU Münster Corrensstraße 36 48149 Münster Germany.ORCID https://orcid.org/0000-0002-3153-6065
Helmholtz Centre for Infection Research · DEHelmholtz Institute for Pharmaceutical Research Saarland · DEUniversity of Münster · DEUniversity Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single site OH → F substitution at the termini of maltotetraose leads to significantly improved hydrolytic stability towards α-amylase and α-glucosidase relative to the natural compound. To explore the effect of molecular editing, selectively modified oligosaccharides were prepared

Identifiers

PMID34163891
PMCPMC8179167
OpenAlexW3107566730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.