Evidence map›Paper›PMID 34163856›Full record

ArticleChemical science2020

Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands.

Sarah-Jane Richards, Tessa Keenan, Jean-Baptiste Vendeville, David E Wheatley, Harriet Chidwick, Darshita Budhadev, Claire E Council, Claire S Webster, Helene Ledru, Alexander N Baker and 5 more

Abstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  4. Article
  5. Article
  6. Selected strategies to fight pathogenic bacteria.Journal of enzyme inhibition and medicinal chemistry · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Selective synthesis ofFrontiers in chemistry · 2022
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sarah-Jane RichardsDepartment of Chemistry, University of Warwick CV4 7AL UK m.i.gibson@warwick.ac.uk.ORCID https://orcid.org/0000-0003-3888-9290
Tessa KeenanDepartment of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.ORCID https://orcid.org/0000-0003-2466-6918
Jean-Baptiste VendevilleSchool of Chemistry, University of Southampton Highfield Southampton SO171BJ UK bruno.linclau@soton.ac.uk.ORCID https://orcid.org/0000-0002-5790-6968
David E WheatleySchool of Chemistry, University of Southampton Highfield Southampton SO171BJ UK bruno.linclau@soton.ac.uk.ORCID https://orcid.org/0000-0002-5075-5554
Harriet ChidwickDepartment of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.
Darshita BudhadevDepartment of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.ORCID https://orcid.org/0000-0002-7899-0759
Claire E CouncilSchool of Chemistry, University of Southampton Highfield Southampton SO171BJ UK bruno.linclau@soton.ac.uk.ORCID https://orcid.org/0000-0003-0600-4689
Claire S WebsterSchool of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK.
Helene LedruSchool of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK.
Alexander N BakerDepartment of Chemistry, University of Warwick CV4 7AL UK m.i.gibson@warwick.ac.uk.ORCID https://orcid.org/0000-0001-6019-3412
Marc WalkerDepartment of Physics, University of Warwick CV4 7AL UK.ORCID https://orcid.org/0000-0002-5522-0516
M Carmen GalanSchool of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK.ORCID https://orcid.org/0000-0001-7307-2871
Bruno LinclauSchool of Chemistry, University of Southampton Highfield Southampton SO171BJ UK bruno.linclau@soton.ac.uk.ORCID https://orcid.org/0000-0001-8762-0170
Martin A FascioneDepartment of Chemistry, University of York Heslington York YO10 5DD UK martin.fascione@york.ac.uk.ORCID https://orcid.org/0000-0002-0066-4419
Matthew I GibsonDepartment of Chemistry, University of Warwick CV4 7AL UK m.i.gibson@warwick.ac.uk.ORCID https://orcid.org/0000-0002-8297-1278

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Galectins are potential biomarkers and therapeutic targets. However, galectins display broad affinity towards β-galactosides meaning glycan-based (nano)biosensors lack the required selectivity and affinity. Using a polymer-stabilized nanoparticle biosensing platform, we herein demonstrate that the specificity of immobilised lacto-

Identifiers

PMID34163856
PMCPMC8179109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.