ArticleChemical science2021
Synthesis of 1,3-disubstituted bicyclo[1.1.0]butanes
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- A Scalable Stereoselective Synthesis of Polysubstituted Housanes.Organic letters · 2026Article
- Stereocontrolled Synthesis of Polysubstituted Housanes viaJournal of the American Chemical Society · 2026Article
- Propellane-free access to bicyclo[1.1.1]pentanes.Nature communications · 2026Review
- Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol.Angewandte Chemie (International ed. in English) · 2025Article
- Direct Synthesis of Bicyclo[1.1.1]pentanes by Sequential C═C, C-C Functionalization Reactions.Journal of the American Chemical Society · 2025Article
- Catalyst-Controlled Divergent Synthesis of Bicyclo[2.1.1]hexanes and Cyclobutenes: The Unique Effect of Au(I).JACS Au · 2025Article
- Facile Synthesis of Housanes by an Unexpected Strategy.Journal of the American Chemical Society · 2025Article
- Synthesis of 1-(phenylsulfonyl)bicyclo[1.1.0]butane from Methyl Phenyl Sulfone and Epichlorohydrin.Organic syntheses; an annual publication of satisfactory methods for the preparation of organic chemicals · 2025Article
- Lewis acid-catalyzed diastereoselective formal ene reaction of thioindolinones/thiolactams with bicyclobutanes.Chemical science · 2024Article
- Three-dimensional saturated C(spNature reviews. Chemistry · 2024Review
- Synthesis of Stereodefined Polysubstituted Bicyclo[1.1.0]butanes.Journal of the American Chemical Society · 2024Article
- Overcoming a Radical Polarity Mismatch in Strain-Release Pentafluorosulfanylation of [1.1.0]Bicyclobutanes: An Entryway to Sulfone- and Carbonyl-Containing SFAngewandte Chemie (International ed. in English) · 2024Article
- Umpolung reactivity of strained C-C σ-bonds without transition-metal catalysis.Nature communications · 2024Article
- Strain-enabled radical spirocyclization cascades: rapid access to spirocyclobutyl lactones and - lactams.Chemical science · 2024Article
- Taming nonclassical carbocations to control small ring reactivity.Science advances · 2024Article
- Bridge Cross-Coupling of Bicyclo[1.1.0]butanes.Organic letters · 2024Article
- Stereoselective Alder-Ene Reactions of Bicyclo[1.1.0]butanes: Facile Synthesis of Cyclopropyl- and Aryl-Substituted Cyclobutenes.Journal of the American Chemical Society · 2024Article
- Review
- Lewis acid-catalyzed diastereoselective carbofunctionalization of bicyclobutanes employing naphthols.Chemical science · 2023Article
- Synthesis and Applications of Bicyclo[1.1.0]butyl and Azabicyclo[1.1.0]butyl Organometallics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bicyclo[1.1.0]butanes (BCBs) are increasingly valued as intermediates in 'strain release' chemistry for the synthesis of substituted four membered rings and bicyclo[1.1.1]pentanes, with applications including bioconjugation processes. Variation of the BCB bridgehead substituents can be challenging due to the inherent strain of the bicyclic scaffold, often necessitating linear syntheses of specific BCB targets. Here we report the first palladium catalyzed cross-coupling on pre-formed BCBs which enables a 'late stage' diversification of the bridgehead position, and the conversion of the resultant products into a range of useful small ring building blocks.
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Registered trials
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