ArticleChemical science2021
Cooperative copper-squaramide catalysis for the enantioselective N-H insertion reaction with sulfoxonium ylides.
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Enantioselective α,α-Chlorofluorination of Sulfoxonium Ylides.Organic letters · 2026Article
- Accessing acyclic vicinal tetrasubstituted stereocenters via biomimetic Cu/squaramide cooperative catalysed asymmetric Mannich reactions.Nature communications · 2025Article
- Enantioselective Synthesis of α-Oxygenated Ketones via Organocatalytic Formal O-H Bond Insertion of Sulfonium Ylides.Journal of the American Chemical Society · 2025Article
- Multifunctional chiral silanol ligands for enantioselective catalysis.Chemical science · 2025Article
- Recent Developments in Stereoselective Reactions of Sulfoxonium Ylides.Molecules (Basel, Switzerland) · 2025Review
- Dual NHC/HAT-Promoted Esterification to Access α-Aryl Glycines.Advanced synthesis & catalysis · 2025Article
- Enantioselective synthesis of chiral amides by carbene insertion into amide N-H bond.Nature communications · 2024Article
- Enantioselective organocatalytic strategies to access noncanonical α-amino acids.Chemical science · 2024Review
- Electro-oxidative quinylation of sulfides to sulfur ylides in batch and continuous flow.iScience · 2024Article
- Direct trifluoroethylation of carbonyl sulfoxonium ylides using hypervalent iodine compounds.Beilstein journal of organic chemistry · 2024Article
- Single-Flask Enantioselective Synthesis of α-Amino Acid Esters by Organocatalysis.Organic letters · 2023Article
- Article
- Visible-light-induced organocatalytic enantioselective N-H insertion of α-diazoesters enabled by indirect free carbene capture.Chemical science · 2023Article
- Article
- Synthesis of INature communications · 2022Article
- Organocatalytic asymmetric azidation of sulfoxonium ylides: mild synthesis of enantioenriched α-azido ketones bearing a labile tertiary stereocenter.Chemical science · 2022Article
- Asymmetric transformations from sulfoxonium ylides.Chemical science · 2022Review
- Organocatalytic asymmetric synthesis of α-amino esters from sulfoxonium ylides.Chemical science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The first examples of a highly efficient and enantioselective carbene-mediated insertion reaction, from a sulfur ylide, are described. By way of a catalytic asymmetric insertion reaction into N-H bonds from carbonyl sulfoxonium ylides and anilines, using a copper-bifunctional squaramide cooperative catalysis approach, thirty-seven α-arylglycine esters were synthesized in enantiomeric ratios up to 92 : 8 (99 : 1 after a single recrystallization) and reaction yields ranging between 49-96%. Furthermore, the protocol benefits from quick reaction times and is conducted in a straightforward manner.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.