ArticleChemical science2021
Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy.
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Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 13 citations in OpenAlex.
- Immature and mature myocardium in the pathophysiology of hypertrophic cardiomyopathy.Journal of molecular and cellular cardiology plus · 2026Review
- Hypertrophic cardiomyopathy-linked Tnnc1 variants are associated with distinct myopathic changes in slow skeletal muscle of mice.Journal of muscle research and cell motility · 2026Article
- Article
- Porcine Left Atrial and Ventricular Thick Filaments Exhibit Distinct Resting Structures and Calcium-dependent Responses.bioRxiv : the preprint server for biology · 2026Article
- Cardiac Troponin C E135A Variant Impairs Myofilament Response to PKA Phosphorylation and Is Associated With Autosomal Dominant Dilated Cardiomyopathy With Diastolic Dysfunction.Circulation. Genomic and precision medicine · 2025Article
- Frustration in physiology and molecular medicine.Molecular aspects of medicine · 2025Review
- The role of mechanosignaling in the control of myocardial mass.American journal of physiology. Heart and circulatory physiology · 2025Review
- Eucommiae Folium and Active Compounds Protect Against Mitochondrial Dysfunction-Calcium Overload in Epileptic Hippocampal Neurons Through the Hypertrophic Cardiomyopathy Pathway.Neurochemical research · 2023Article
- Mouse Models of Cardiomyopathies Caused by Mutations in Troponin C.International journal of molecular sciences · 2023Review
- A perspective on Notch signalling in progression and arrhythmogenesis in familial hypertrophic and dilated cardiomyopathies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The effect of MgThe FEBS journal · 2022Article
- Mandibular muscle troponin of the Florida carpenter ant Camponotus floridanus: extending our insights into invertebrate CaJournal of muscle research and cell motility · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 5 countries.
Mayra A MarquesInstitute of Medical Biochemistry Leopoldo de Meis, National Institute of Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro 373 Carlos Chagas Filho Av, Room: E-10 Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br +55-21-3938-6756.ORCID https://orcid.org/0000-0002-4131-4634
Maicon Landim-VieiraDepartment of Biomedical Sciences, Florida State University, College of Medicine 1115 West Call Street, Room: 1370 (lab) - 1350-H (office) Tallahassee FL 32306 USA jose.pinto@med.fsu.edu +1-850-645-0016.ORCID https://orcid.org/0000-0002-6696-8888
Adolfo H MoraesDepartment of Chemistry, Federal University of Minas Gerais Belo Horizonte MG Brazil.ORCID https://orcid.org/0000-0002-3344-4084
Bin SunDepartment of Cell and Molecular Physiology, Loyola University Chicago Maywood IL USA.
Jamie R JohnstonDepartment of Biomedical Sciences, Florida State University, College of Medicine 1115 West Call Street, Room: 1370 (lab) - 1350-H (office) Tallahassee FL 32306 USA jose.pinto@med.fsu.edu +1-850-645-0016.
Karissa M Dieseldorff JonesDepartment of Biomedical Sciences, Florida State University, College of Medicine 1115 West Call Street, Room: 1370 (lab) - 1350-H (office) Tallahassee FL 32306 USA jose.pinto@med.fsu.edu +1-850-645-0016.
Elio A CinoDepartment of Biochemistry and Immunology, Federal University of Minas Gerais Belo Horizonte MG Brazil.
Michelle S ParvatiyarDepartment of Nutrition, Food and Exercise Sciences, Florida State University Tallahassee FL USA.
Isela C ValeraDepartment of Nutrition, Food and Exercise Sciences, Florida State University Tallahassee FL USA.
Jerson L SilvaInstitute of Medical Biochemistry Leopoldo de Meis, National Institute of Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro 373 Carlos Chagas Filho Av, Room: E-10 Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br +55-21-3938-6756.ORCID https://orcid.org/0000-0001-9523-9441
Vitold E GalkinDepartment of Physiological Sciences, Eastern Virginia Medical School Norfolk VA USA.
P Bryant ChaseDepartment of Biological Science, Florida State University Tallahassee FL USA.ORCID https://orcid.org/0000-0001-9701-561X
Peter M Kekenes-HuskeyDepartment of Cell and Molecular Physiology, Loyola University Chicago Maywood IL USA.
Guilherme A P de OliveiraInstitute of Medical Biochemistry Leopoldo de Meis, National Institute of Structural Biology and Bioimaging, National Center of Nuclear Magnetic Resonance Jiri Jonas, Federal University of Rio de Janeiro 373 Carlos Chagas Filho Av, Room: E-10 Rio de Janeiro RJ 21941-902 Brazil gaugusto@bioqmed.ufrj.br +55-21-3938-6756.ORCID https://orcid.org/0000-0002-0063-5888
Jose Renato PintoDepartment of Biomedical Sciences, Florida State University, College of Medicine 1115 West Call Street, Room: 1370 (lab) - 1350-H (office) Tallahassee FL 32306 USA jose.pinto@med.fsu.edu +1-850-645-0016.ORCID https://orcid.org/0000-0001-9092-4976
Florida State University · USUniversidade Federal do Rio de Janeiro · BRLoyola University Chicago · USUniversidade Federal de Minas Gerais · BREastern Virginia Medical School · US
Funding
PROBING CELLULAR INTRACELLULAR CALCIUM SIGNALING AND SENSING THROUGH COMPUTATIONR35GM124977 · NIGMS · UNIVERSITY OF KENTUCKY · PI KEKENES-HUSKEY, PETER MICHAEL · 2017 to 2021
$1.8MModulators of Cardiomyopathic DiseasesR01HL128683 · NHLBI · FLORIDA STATE UNIVERSITY · PI PINTO, JOSE RENATO · 2016 to 2020
$1.8MReversal of Hypertrophic Cardiomyopathy via Conditional Ablation of Cardiac Myosin Light Chain KinaseF31HL137408 · NHLBI · FLORIDA STATE UNIVERSITY · PI DIESELDORFF JONES, KARISSA M · 2017 to 2019
$105kNHLBI NIH HHS F31 HL137408NHLBI NIH HHS R01 HL128683NIGMS NIH HHS R35 GM124977
Abstract
Cardiac TnC (cTnC) is highly conserved among mammals, and genetic variants can result in disease by perturbing Ca
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.