Evidence map›Paper›PMID 34163804›Full record

ArticleChemical science2020

Unusual light-driven amplification through unexpected regioselective photogeneration of five-membered azaheterocyclic AIEgen.

Qiyao Li, Junyi Gong, Ying Li, Ruoyao Zhang, Haoran Wang, Jianquan Zhang, He Yan, Jacky W Y Lam, Herman H Y Sung, Ian D Williams and 4 more

Abstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qiyao LiDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Nanoscience, Division of Life Science, Department of Chemical and Biomedical Engineering and Institute for Advanced Study, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China tangbenz@ust.hk.
Junyi GongDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Nanoscience, Division of Life Science, Department of Chemical and Biomedical Engineering and Institute for Advanced Study, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China tangbenz@ust.hk.ORCID https://orcid.org/0000-0001-7592-7132
Ying LiDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Nanoscience, Division of Life Science, Department of Chemical and Biomedical Engineering and Institute for Advanced Study, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China tangbenz@ust.hk.
Ruoyao ZhangDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Nanoscience, Division of Life Science, Department of Chemical and Biomedical Engineering and Institute for Advanced Study, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China tangbenz@ust.hk.
Haoran WangDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Nanoscience, Division of Life Science, Department of Chemical and Biomedical Engineering and Institute for Advanced Study, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China tangbenz@ust.hk.
Jianquan ZhangDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Nanoscience, Division of Life Science, Department of Chemical and Biomedical Engineering and Institute for Advanced Study, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China tangbenz@ust.hk.
He YanDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Nanoscience, Division of Life Science, Department of Chemical and Biomedical Engineering and Institute for Advanced Study, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China tangbenz@ust.hk.ORCID https://orcid.org/0000-0003-1780-8308
Jacky W Y LamDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Nanoscience, Division of Life Science, Department of Chemical and Biomedical Engineering and Institute for Advanced Study, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China tangbenz@ust.hk.
Herman H Y SungDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Nanoscience, Division of Life Science, Department of Chemical and Biomedical Engineering and Institute for Advanced Study, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China tangbenz@ust.hk.
Ian D WilliamsDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Nanoscience, Division of Life Science, Department of Chemical and Biomedical Engineering and Institute for Advanced Study, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China tangbenz@ust.hk.ORCID https://orcid.org/0000-0001-8743-401X
Ryan T K KwokDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Nanoscience, Division of Life Science, Department of Chemical and Biomedical Engineering and Institute for Advanced Study, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China tangbenz@ust.hk.
Min-Hui LiChimie ParisTech, PSL University Paris, CNRS, Institut de Recherche de Chimie Paris Paris 75005 France.ORCID https://orcid.org/0000-0001-5367-0348
Jianguo WangCollege of Chemistry and Chemical Engineering, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University Hohhot 010021 China.ORCID https://orcid.org/0000-0003-0984-9716
Ben Zhong TangDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Molecular Nanoscience, Division of Life Science, Department of Chemical and Biomedical Engineering and Institute for Advanced Study, The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China tangbenz@ust.hk.ORCID https://orcid.org/0000-0002-0293-964X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing versatile synthetic methodologies with merits of simplicity, efficiency, and environment friendliness for five-membered heterocycles is of incredible importance to pharmaceutical and material science, as well as a huge challenge to synthetic chemistry. Herein, an unexpected regioselective photoreaction to construct a fused five-membered azaheterocycle with an aggregation-induced emission (AIE) characteristic is developed under mild conditions. The formation of the five-membered ring is both thermodynamically and kinetically favored, as justified by theoretical calculation and experimental evidence. Markedly, a light-driven amplification strategy is proposed and applied in selective mitochondria-targeted cancer cell recognition and fluorescent photopattern fabrication with improved resolution. The work not only delivers the first report on efficiently generating a fused five-membered azaheterocyclic AIE luminogen under mild conditions

Identifiers

PMID34163804
PMCPMC8179000

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.