ArticleChemical science2021
A highly selective decarboxylative deuteration of carboxylic acids.
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Photocatalyst-free photochemical deuteration via H/D exchange with DNature communications · 2025Article
- Pyridoxal-Inspired Photo-Decarboxylase Catalysis: Photochemical Decarboxylation of Unprotected Amino Acids.Angewandte Chemie (International ed. in English) · 2025Article
- Efficient and modular synthesis of ibogaine and related alkaloids.Nature chemistry · 2025Article
- Substitution, Elimination, and Integration of Methyl Groups in Terpenes Initiated by C-H Bond Functionalization.ACS central science · 2024Article
- Hydro- and deutero-deamination of primary amines using O-diphenylphosphinylhydroxylamine.Nature communications · 2024Article
- Selective monodeuteration enabled by bisphosphonium catalyzed ring opening processes.Nature communications · 2024Article
- Photocatalyzed hydrodecarboxylation of fatty acids: a prospective method to produce drop-in biofuels.RSC advances · 2024Article
- Article
- Arylcarboxylation of unactivated alkenes with CONature communications · 2023Article
- Chemoselective Decarboxylative Protonation Enabled by Cooperative Earth-Abundant Element Catalysis.Angewandte Chemie (International ed. in English) · 2023Article
- Highly selective single and multiple deuteration of unactivated C(spNature communications · 2022Article
- Site-Specific and Degree-Controlled Alkyl Deuteration via Cu-Catalyzed Redox-Neutral Deacylation.Journal of the American Chemical Society · 2022Article
- Decarboxylative tandem C-N coupling with nitroarenes via SNature communications · 2022Article
- Titanocene(III)-Catalyzed Precision Deuteration of Epoxides.Angewandte Chemie (International ed. in English) · 2022Article
- Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry.Chemical reviews · 2022Review
- Photocatalytic decarboxylative amidosulfonation enables direct transformation of carboxylic acids to sulfonamides.Chemical science · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we report a mild and practical method for precise deuteration of aliphatic carboxylic acids by synergistic photoredox and HAT catalysis. The reaction delivers excellent D-incorporation (up to 99%) at predicted sites even in substrates bearing reactive C-H bonds or versatile functional groups. The use of a recirculation reactor with a peristaltic pump supports a scalable preparative ability (up to 50 mmol) under very mild reaction conditions. The practical and precise deuteration of readily available complex carboxylic acids makes this protocol promising for the preparation of deuterium-labelled compounds.
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