Evidence map›Paper›PMID 34163756›Full record

ArticleChemical science2021

Rapid and ultrasensitive electrochemical detection of circulating tumor DNA by hybridization on the network of gold-coated magnetic nanoparticles.

Dongfei Chen, Yanfang Wu, Sharmin Hoque, Richard D Tilley, J Justin Gooding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dongfei ChenSchool of Chemistry, The University of New South Wales Sydney NSW 2052 Australia justin.gooding@unsw.edu.au.
Yanfang WuSchool of Chemistry, The University of New South Wales Sydney NSW 2052 Australia justin.gooding@unsw.edu.au.ORCID https://orcid.org/0000-0003-4201-2061
Sharmin HoqueSchool of Chemistry, The University of New South Wales Sydney NSW 2052 Australia justin.gooding@unsw.edu.au.
Richard D TilleySchool of Chemistry, The University of New South Wales Sydney NSW 2052 Australia justin.gooding@unsw.edu.au.ORCID https://orcid.org/0000-0003-2097-063X
J Justin GoodingSchool of Chemistry, The University of New South Wales Sydney NSW 2052 Australia justin.gooding@unsw.edu.au.ORCID https://orcid.org/0000-0002-5398-0597

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An accurate and robust method for quantifying the levels of circulating tumor DNA (ctDNA) is vital if this potential biomarker is to be used for the early diagnosis of cancer. The analysis of ctDNA presents unique challenges because of its short half-life and ultralow abundance in early stage cancers. Here we develop an ultrasensitive electrochemical biosensor for rapid detection of ctDNA in whole blood. The sensing of ctDNA is based on hybridization on a network of probe DNA modified gold-coated magnetic nanoparticles (DNA-Au@MNPs). This DNA-Au@MNPs biosensor can selectively detect short- and long-strand DNA targets. It has a broad dynamic range (2 aM to 20 nM) for 22 nucleotide DNA target with an ultralow detection limit of 3.3 aM. For 101 nucleotide ctDNA target, a dynamic range from 200 aM to 20 nM was achieved with a detection limit of 5 fM. This DNA-Au@MNPs based sensor provides a promising method to achieve 20 min response time and minimally invasive cancer early diagnosis.

Identifiers

PMID34163756
PMCPMC8179593

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.