ReviewChemical science2021
NHC-catalyzed covalent activation of heteroatoms for enantioselective reactions.
Review in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Cooperative NHC and Photoredox Dual Catalysis for the Construction of Carbonyl Compounds.ACS omega · 2026Review
- Carbon and Heteroatom Activation via N-Heterocyclic Carbene-Bound Dearomative Intermediates for Stereoselective Annulation Reactions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Mechanochemistry for Organic and Inorganic Synthesis.ACS organic & inorganic Au · 2024Review
- N-heterocyclic carbene catalyzed [2 + 3] annulation reaction for the synthesis of trifluoroethyl 3,2'-spirooxindole γ-lactam.RSC advances · 2024Article
- Construction of Highly Functionalized 2-Styrylfurans by N-Heterocyclic Carbene/Brønsted Acid Catalysis.Organic letters · 2024Article
- Enantioselective [3 + 3] Annulation-Deoxalation Strategy for Rapid Access to δ-Oxoesters via N-Heterocyclic Carbene Catalysis.Organic letters · 2024Article
- Recent advances in combining photo- and N-heterocyclic carbene catalysis.Chemical science · 2023Review
- Construction of Non-Biaryl Atropisomeric Amide Scaffolds Bearing a C-N Axis via Enantioselective Catalysis.Molecules (Basel, Switzerland) · 2022Review
- Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones.Molecules (Basel, Switzerland) · 2022Article
- The Role of the Fused Ring in Bicyclic Triazolium Organocatalysts: Kinetic, X-ray, and DFT Insights.The Journal of organic chemistry · 2022Article
- Tale of the Breslow intermediate, a central player in N-heterocyclic carbene organocatalysis: then and now.Chemical science · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Covalent activation of heteroatoms enabled by N-heterocyclic carbene (NHC) organic catalysts for enantioselective reactions is evaluated and summarized in this review. To date, sulfur, oxygen, and nitrogen atoms can be activated in this manner to react with another substrate to construct chiral carbon-heteroatom bonds with high optical enantioselectivities. The activation starts with addition of an NHC catalyst to the carbonyl moiety (aldehyde or imine) of substrates that contain heteroatoms. The key in this approach is the formation of intermediates covalently bound to the NHC catalyst, in which the heteroatom of the substrate is activated as a nucleophilic reactive site.
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Registered trials
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