ArticleChemical science2021
Controlled mutation in the replication of synthetic oligomers.
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Coordination-Driven Orthogonal Ligand Pairings through Dual Hydrogen-Bonding/π-π Interaction Complementarity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Covalent Template-Directed Synthesis: A Powerful Tool for the Construction of Complex Molecules.Chemical reviews · 2025Review
- Replication of synthetic recognition-encoded oligomers by ligation of trimer building blocks.Organic chemistry frontiers : an international journal of organic chemistry · 2023Article
- Sequence-selective duplex formation and template effect in recognition-encoded oligoanilines.Chemical science · 2023Article
- Effect of backbone flexibility on covalent template-directed synthesis of linear oligomers.Organic & biomolecular chemistry · 2022Article
- Replication of a synthetic oligomer using chameleon base-pairs.Chemical communications (Cambridge, England) · 2022Article
- H-Bond Templated Oligomer Synthesis Using a Covalent Primer.Journal of the American Chemical Society · 2022Article
- Controlled mutation rates in synthetic replicators.Communications chemistry · 2021Article
- Replication of Sequence Information in Synthetic Oligomers.Accounts of chemical research · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Replication of sequence information with mutation is the molecular basis for the evolution of functional biopolymers. Covalent template-directed synthesis has been used to replicate sequence information in synthetic oligomers, and the covalent base-pairs used in these systems provide an opportunity to manipulate the outcome of the information transfer process through the use of traceless linkers. Two new types of covalent base-pair have been used to introduce mutation in the replication of an oligotriazole, where information is encoded as the sequence of benzoic acid and phenol monomer units. When a benzoic acid-benzoic acid base-pairing system was used, a direct copy of a benzoic acid homo-oligomer template was obtained. When a phenol-benzoic acid base-pairing system was used, a reciprocal copy, the phenol homo-oligomer, was obtained. The two base-pairing systems are isosteric, so they can be used interchangeably, allowing direct and reciprocal copying to take place simultaneously on the same template strand. As a result, it was possible to introduce mutations in the replication process by spiking the monomer used for direct copying with the monomer used for reciprocal copying. The mutation rate is determined precisely by the relative proportions of the two monomers. The ability to introduce mutation at a controlled rate is a key step in the development of synthetic systems capable of evolution, which requires replication with variation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.