Evidence map›Paper›PMID 34163676›Full record

ArticleChemical science2021

Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin.

Zoltan Dekan, Thomas Kremsmayr, Peter Keov, Mathilde Godin, Ngari Teakle, Leopold Dürrauer, Huang Xiang, Dalia Gharib, Christian Bergmayr, Roland Hellinger and 7 more

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Design, synthesis, conformational analysis, and biological activity of CαJournal of enzyme inhibition and medicinal chemistry · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation.International journal of molecular sciences · 2021
    Review
  10. Conformational selection of vasopressin upon VComputational and structural biotechnology journal · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 6 countries.

Zoltan DekanInstitute for Molecular Bioscience, The University of Queensland Brisbane 4072 Australia m.muttenthaler@uq.edu.au.ORCID https://orcid.org/0000-0002-6841-4176
Thomas KremsmayrInstitute of Biological Chemistry, University of Vienna Währingerstraße 38 1090 Vienna Austria markus.muttenthaler@univie.ac.at.ORCID https://orcid.org/0000-0003-0630-2555
Peter KeovFaculty of Medicine, School of Biomedical Sciences, The University of Queensland Brisbane 4072 Australia.ORCID https://orcid.org/0000-0002-3829-6455
Mathilde GodinInstitute for Molecular Bioscience, The University of Queensland Brisbane 4072 Australia m.muttenthaler@uq.edu.au.
Ngari TeakleInstitute for Molecular Bioscience, The University of Queensland Brisbane 4072 Australia m.muttenthaler@uq.edu.au.
Leopold DürrauerInstitute of Biological Chemistry, University of Vienna Währingerstraße 38 1090 Vienna Austria markus.muttenthaler@univie.ac.at.
Huang XiangCenter for Physiology and Pharmacology, Medical University of Vienna Schwarzspanierstraße 17 1090 Vienna Austria christian.w.gruber@meduniwien.ac.at.
Dalia GharibCenter for Physiology and Pharmacology, Medical University of Vienna Schwarzspanierstraße 17 1090 Vienna Austria christian.w.gruber@meduniwien.ac.at.
Christian BergmayrCenter for Physiology and Pharmacology, Medical University of Vienna Schwarzspanierstraße 17 1090 Vienna Austria christian.w.gruber@meduniwien.ac.at.
Roland HellingerCenter for Physiology and Pharmacology, Medical University of Vienna Schwarzspanierstraße 17 1090 Vienna Austria christian.w.gruber@meduniwien.ac.at.ORCID https://orcid.org/0000-0002-8955-8793
Marina GayInstitute for Research in Biomedicine Barcelona C/ Baldiri Reixac 10 08028 Barcelona Spain.ORCID https://orcid.org/0000-0002-8827-7092
Marta VilasecaInstitute for Research in Biomedicine Barcelona C/ Baldiri Reixac 10 08028 Barcelona Spain.ORCID https://orcid.org/0000-0002-1666-1300
Dennis KurzbachInstitute of Biological Chemistry, University of Vienna Währingerstraße 38 1090 Vienna Austria markus.muttenthaler@univie.ac.at.ORCID https://orcid.org/0000-0001-6455-2136
Fernando AlbericioDepartment of Organic Chemistry, University of Barcelona Barcelona Science Park, Baldiri Reixac 10 08028 Barcelona Spain.ORCID https://orcid.org/0000-0002-8946-0462
Paul F AlewoodInstitute for Molecular Bioscience, The University of Queensland Brisbane 4072 Australia m.muttenthaler@uq.edu.au.ORCID https://orcid.org/0000-0001-7454-6522
Christian W GruberFaculty of Medicine, School of Biomedical Sciences, The University of Queensland Brisbane 4072 Australia.ORCID https://orcid.org/0000-0001-6060-7048
Markus MuttenthalerInstitute for Molecular Bioscience, The University of Queensland Brisbane 4072 Australia m.muttenthaler@uq.edu.au.ORCID https://orcid.org/0000-0003-1996-4646
The University of Queensland · AUMedical University of Vienna · ATUniversity of Vienna · ATInstitute for Research in Biomedicine · ESFC Barcelona · ES

Funding

Austrian Science Fund FWF I 3243Austrian Science Fund FWF P 32109
6 · The paper itself

Abstract

Vasopressin (VP) and oxytocin (OT) are cyclic neuropeptides that regulate fundamental physiological functions

Identifiers

PMID34163676
PMCPMC8179488
OpenAlexW3127434964

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.