Evidence map›Paper›PMID 34163649›Full record

ArticleChemical science2021

Design, scope and mechanism of highly active and selective chiral NHC-iridium catalysts for the intramolecular hydroamination of a variety of unactivated aminoalkenes.

Daven Foster, Pengchao Gao, Ziyun Zhang, Gellért Sipos, Alexandre N Sobolev, Gareth Nealon, Laura Falivene, Luigi Cavallo, Reto Dorta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daven FosterDepartment of Chemistry, School of Molecular Sciences, University of Western Australia M310, 35 Stirling Highway 6009 Perth WA Australia reto.dorta@uwa.edu.au.
Pengchao GaoDepartment of Chemistry, School of Molecular Sciences, University of Western Australia M310, 35 Stirling Highway 6009 Perth WA Australia reto.dorta@uwa.edu.au.
Ziyun ZhangKing Abdullah University of Science and Technology (KAUST), Chemical and Life Sciences and Engineering, Kaust Catalysis Center Thuwal 23955-6900 Saudi Arabia.
Gellért SiposDepartment of Chemistry, School of Molecular Sciences, University of Western Australia M310, 35 Stirling Highway 6009 Perth WA Australia reto.dorta@uwa.edu.au.ORCID https://orcid.org/0000-0001-6956-9009
Alexandre N SobolevCentre for Microscopy, Characterisation and Analysis, University of Western Australia 35 Stirling Highway 6009 Perth WA Australia.
Gareth NealonCentre for Microscopy, Characterisation and Analysis, University of Western Australia 35 Stirling Highway 6009 Perth WA Australia.
Laura FaliveneKing Abdullah University of Science and Technology (KAUST), Chemical and Life Sciences and Engineering, Kaust Catalysis Center Thuwal 23955-6900 Saudi Arabia.
Luigi CavalloKing Abdullah University of Science and Technology (KAUST), Chemical and Life Sciences and Engineering, Kaust Catalysis Center Thuwal 23955-6900 Saudi Arabia.ORCID https://orcid.org/0000-0002-1398-338X
Reto DortaDepartment of Chemistry, School of Molecular Sciences, University of Western Australia M310, 35 Stirling Highway 6009 Perth WA Australia reto.dorta@uwa.edu.au.ORCID https://orcid.org/0000-0003-1240-2755

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chiral, cationic NHC-iridium complexes are introduced as catalysts for the intramolecular hydroamination reaction of unactivated aminoalkenes. The catalysts show high activity in the construction of a range of 5- and 6-membered N-heterocycles, which are accessed in excellent optical purity, with various functional groups being tolerated with this system. A major deactivation pathway is presented and eliminated by using alternative reaction conditions. A detailed experimental and computational study on the reaction mechanism is performed providing valuable insights into the mode of action of the catalytic system and pointing to future modifications to be made for this catalytic platform.

Identifiers

PMID34163649
PMCPMC8179506

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.