Evidence map›Paper›PMID 34163647›Full record

ArticleChemical science2021

Towards the stable chelation of radium for biomedical applications with an 18-membered macrocyclic ligand.

Diane S Abou, Nikki A Thiele, Nicholas T Gutsche, Alexandria Villmer, Hanwen Zhang, Joshua J Woods, Kwamena E Baidoo, Freddy E Escorcia, Justin J Wilson, Daniel L J Thorek

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
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  4. Rapid and Accurate Determination ofAnalytical chemistry · 2026
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  16. Chelation of [Dalton transactions (Cambridge, England : 2003) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Diane S AbouDepartment of Radiology, Washington University in St. Louis School of Medicine St. Louis MO 63110 USA thorek.lab@wustl.edu.ORCID https://orcid.org/0000-0002-3005-9623
Nikki A ThieleDepartment of Chemistry and Chemical Biology, Cornell University Ithaca NY 14853 USA jjw275@cornell.edu.ORCID https://orcid.org/0000-0003-3301-0849
Nicholas T GutscheMolecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda MD 20892 USA.
Alexandria VillmerDepartment of Radiology, Washington University in St. Louis School of Medicine St. Louis MO 63110 USA thorek.lab@wustl.edu.
Hanwen ZhangDepartment of Radiology, Washington University in St. Louis School of Medicine St. Louis MO 63110 USA thorek.lab@wustl.edu.ORCID https://orcid.org/0000-0001-7710-5116
Joshua J WoodsDepartment of Chemistry and Chemical Biology, Cornell University Ithaca NY 14853 USA jjw275@cornell.edu.ORCID https://orcid.org/0000-0002-6213-4093
Kwamena E BaidooMolecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda MD 20892 USA.
Freddy E EscorciaMolecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda MD 20892 USA.ORCID https://orcid.org/0000-0002-0727-3242
Justin J WilsonDepartment of Chemistry and Chemical Biology, Cornell University Ithaca NY 14853 USA jjw275@cornell.edu.ORCID https://orcid.org/0000-0002-4086-7982
Daniel L J ThorekDepartment of Radiology, Washington University in St. Louis School of Medicine St. Louis MO 63110 USA thorek.lab@wustl.edu.ORCID https://orcid.org/0000-0003-2437-1239
Washington University in St. Louis · USNational Institutes of Health · USCornell University · USOak Ridge National Laboratory · US

Funding

Engineering HCC-selective PET agentZIABC011800 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ESCORCIA, FREDDY · 2018 to 2025
$10.6M
Chelation strategies for s-, p-, and f-block radionuclides for targeted alpha therapyR01EB029259 · NIBIB · CORNELL UNIVERSITY · PI WILSON, JUSTIN J · 2020 to 2023
$1.4M
Expanding the Therapeutic Potential of the Alpha Emitter Radium-223R21EB027282 · NIBIB · CORNELL UNIVERSITY · PI WILSON, JUSTIN J · 2019 to 2021
$619k
6 · The paper itself

Abstract

Targeted alpha therapy is an emerging strategy for the treatment of disseminated cancer. [

Identifiers

PMID34163647
PMCPMC8179459
OpenAlexW3127869214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.