Evidence map›Paper›PMID 34163615›Full record

ReviewChemical science2021

Fluorescent small organic probes for biosensing.

Xue Tian, Lloyd C Murfin, Luling Wu, Simon E Lewis, Tony D James

Abstract readReview
In one paragraph

Review in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Tuning probe permeabilityChemical science · 2025
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xue TianDepartment of Chemistry, University of Bath Bath BA2 7AY UK lw960@bath.ac.uk s.e.lewis@bath.ac.uk t.d.james@bath.ac.uk.ORCID https://orcid.org/0000-0002-9494-3493
Lloyd C MurfinDepartment of Chemistry, University of Bath Bath BA2 7AY UK lw960@bath.ac.uk s.e.lewis@bath.ac.uk t.d.james@bath.ac.uk.ORCID https://orcid.org/0000-0003-4780-9539
Luling WuDepartment of Chemistry, University of Bath Bath BA2 7AY UK lw960@bath.ac.uk s.e.lewis@bath.ac.uk t.d.james@bath.ac.uk.ORCID https://orcid.org/0000-0001-6574-5861
Simon E LewisDepartment of Chemistry, University of Bath Bath BA2 7AY UK lw960@bath.ac.uk s.e.lewis@bath.ac.uk t.d.james@bath.ac.uk.ORCID https://orcid.org/0000-0003-4555-4907
Tony D JamesDepartment of Chemistry, University of Bath Bath BA2 7AY UK lw960@bath.ac.uk s.e.lewis@bath.ac.uk t.d.james@bath.ac.uk.ORCID https://orcid.org/0000-0002-4095-2191

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small-molecule based fluorescent probes are increasingly important for the detection and imaging of biological signaling molecules due to their simplicity, high selectivity and sensitivity, whilst being non-invasive, and suitable for real-time analysis of living systems. With this perspective we highlight sensing mechanisms including Förster resonance energy transfer (FRET), intramolecular charge transfer (ICT), photoinduced electron transfer (PeT), excited state intramolecular proton transfer (ESIPT), aggregation induced emission (AIE) and multiple modality fluorescence approaches including dual/triple sensing mechanisms (DSM or TSM). Throughout the perspective we highlight the remaining challenges and suggest potential directions for development towards improved small-molecule fluorescent probes suitable for biosensing.

Identifiers

PMID34163615
PMCPMC8179477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.