Evidence map›Paper›PMID 34163472›Full record

ArticleFrontiers in immunology2021

Immunoregulatory Monocyte Subset Promotes Metastasis Associated With Therapeutic Intervention for Primary Tumor.

Takumi Shibuya, Asami Kamiyama, Hirotaka Sawada, Kenta Kikuchi, Mayu Maruyama, Rie Sawado, Naoki Ikeda, Kenichi Asano, Daisuke Kurotaki, Tomohiko Tamura and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Targeting Lineage-Specific Functions of NR4A1 for Cancer Immunotherapy.International journal of molecular sciences · 2025
    Review
  6. Review
  7. Article
  8. Integration analysis of single-cell transcriptome reveals specific monocyte subsets associated with melanoma brain and leptomeningeal metastasis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  9. Article
  10. Article
  11. The Brain Pre-Metastatic Niche: Biological and Technical Advancements.International journal of molecular sciences · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Takumi ShibuyaLaboratory of Immune Regulation, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Asami KamiyamaLaboratory of Immune Regulation, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Hirotaka SawadaLaboratory of Immune Regulation, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Kenta KikuchiLaboratory of Immune Regulation, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Mayu MaruyamaLaboratory of Immune Regulation, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Rie SawadoLaboratory of Immune Regulation, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Naoki IkedaLaboratory of Immune Regulation, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Kenichi AsanoLaboratory of Immune Regulation, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Daisuke KurotakiDepartment of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Tomohiko TamuraDepartment of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Atsuko YonedaLaboratory of Genome and Biosignals, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Keisuke ImadaCenter for Fundamental Laboratory Education, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Takashi SatohDepartment of Immune Regulation, Graduate School and Faculty of Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Shizuo AkiraLaboratory of Host Defense, WPI Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan.
Masato TanakaLaboratory of Immune Regulation, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Satoshi YotsumotoLaboratory of Immune Regulation, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan.
Tokyo University of Pharmacy and Life Sciences · JPYokohama City University · JPOsaka University · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic and local inflammation associated with therapeutic intervention of primary tumor occasionally promotes metastatic recurrence in mouse and human. However, it remains unclear what types of immune cells are involved in this process. Here, we found that the tissue-repair-promoting Ym1

Indexed as

ImmunomodulationAnimalsAntigens, LyBiomarkers, TumorCell Line, TumorCell PlasticityDisease ManagementDisease Models, AnimalDisease SusceptibilityGene Expression Regulation, NeoplasticImmunophenotypingInflammationLung NeoplasmsMatrix Metalloproteinase 9Melanoma, ExperimentalMiceAntigens, LyBiomarkers, TumorCXCR4 protein, mouseMatrix Metalloproteinase 9Receptors, CXCR4atypical monocyteinflammationirradiationlung metastasissurgery

Identifiers

PMID34163472
PMCPMC8215602
OpenAlexW3166586436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.