Evidence map›Paper›PMID 34163464›Full record

ArticleFrontiers in immunology2021

A 8-mer Peptide of PGLYRP1/Tag7 Innate Immunity Protein Binds to TNFR1 Receptor and Inhibits TNFα-Induced Cytotoxic Effect and Inflammation.

Georgii B Telegin, Aleksandr S Chernov, Vitaly A Kazakov, Elena A Romanova, Tatiana N Sharapova, Denis V Yashin, Alexander G Gabibov, Lidia P Sashchenko

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Psoriasis-like disease prevents squamous skin tumor development by neutrophil-driven inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor.International journal of molecular sciences · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Georgii B TeleginAnimal Breeding Facility, Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Pushchino, Russia.
Aleksandr S ChernovAnimal Breeding Facility, Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Pushchino, Russia.
Vitaly A KazakovAnimal Breeding Facility, Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Pushchino, Russia.
Elena A RomanovaLaboratory of Molecular Immunogenetics of Cancer, Institute of Gene Biology Russian Academy of Science, Moscow, Russia.
Tatiana N SharapovaLaboratory of Molecular Immunogenetics of Cancer, Institute of Gene Biology Russian Academy of Science, Moscow, Russia.
Denis V YashinLaboratory of Molecular Immunogenetics of Cancer, Institute of Gene Biology Russian Academy of Science, Moscow, Russia.
Alexander G GabibovLaboratory of Biocatalysis, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.
Lidia P SashchenkoLaboratory of Molecular Immunogenetics of Cancer, Institute of Gene Biology Russian Academy of Science, Moscow, Russia.
Institute of Bioorganic Chemistry · RUInstitute of Gene Biology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Search for novel regulatory protein fragments with potential functional roles is required both for understanding the immune response mechanisms and the development of targeted immunotherapy. Earlier we demonstrated that the PGLYRP1/Tag7 innate immunity protein can be regarded as an inhibitor of TNFα cytotoxic activity

Indexed as

AnimalsArthritis, ExperimentalArthritis, RheumatoidCell LineCytokinesCytotoxicity, ImmunologicDisease Models, AnimalFemaleFibroblastsHumansImmunity, InnateInflammationMicePeptidesProtein BindingReceptors, Tumor Necrosis Factor, Type ICytokinesPeptidesPGLYRP1 protein, humanReceptors, Tumor Necrosis Factor, Type ITumor Necrosis Factor-alpha17.1 and 17.1А peptidesarthritiscomplete Freund’s adjuvantinflammationmiceTag7TNFα

Identifiers

PMID34163464
PMCPMC8215708
OpenAlexW3170802597

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.