Evidence map›Paper›PMID 34163460›Full record

ReviewFrontiers in microbiology2021

It Takes Two to Tango: How a Dysregulation of the Innate Immunity, Coupled With

Andrea Ardizzoni, Robert T Wheeler, Eva Pericolini

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
  2. Differential Virulence of VaginalJournal of fungi (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Exploring the Mechanism of Tannic Acid AgainstPathogens (Basel, Switzerland) · 2026
    Article
  8. Article
  9. Biphasic Regulation of Epithelial Antimicrobial Peptides DuringJournal of fungi (Basel, Switzerland) · 2026
    Article
  10. Article
  11. Article
  12. Evaluation ofFrontiers in microbiology · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Vaginal Clinical Isolates ofJournal of fungi (Basel, Switzerland) · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Andrea ArdizzoniDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Robert T WheelerDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, United States.
Eva PericoliniDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
University of Modena and Reggio Emilia · ITUniversity of Maine · US

Funding

Genetic determinants of bacterial-drug synergy against CandidaR15AI169393 · NIAID · UNIVERSITY OF MAINE ORONO · PI WHEELER, ROBERT T. · 2023 to 2023
$435k
Intravital study of innate immunity to mucosal candidiasisR15AI133415 · NIAID · UNIVERSITY OF MAINE ORONO · PI WHEELER, ROBERT T. · 2018 to 2018
$415k
NIAID NIH HHS R15 AI133415NIAID NIH HHS R15 AI169393
6 · The paper itself

Abstract

Vulvovaginal candidiasis (VVC) is a symptomatic inflammation of the vagina mainly caused by

Indexed as

C. albicansmicrobiotaneutrophilssecreted aspartyl proteases (Sap)vaginal epitheliumvaginal inflammationvirulence factorsvulvovaginal candidiasis (VVC)

Identifiers

PMID34163460
PMCPMC8215348
OpenAlexW3171316100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.