Evidence map›Paper›PMID 34163361›Full record

ArticleFrontiers in pharmacology2021

Cefdinir and β-Lactamase Inhibitor Independent Efficacy Against

Shashikant Srivastava, Tania Thomas, Dave Howe, Lesibana Malinga, Prithvi Raj, Jan-Willem Alffenaar, Tawanda Gumbo

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Cefdinir binding to a class A β-lactamase revealed by serial cryo-crystallography.Acta crystallographica. Section D, Structural biology · 2026
    Article
  2. Sanfetrinem, an oral β-lactam antibiotic repurposed for the treatment of tuberculosis.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Shashikant SrivastavaDepartment of Pulmonary Immunology, University of Texas Health Science Centre, Tyler, TX, United States.
Tania ThomasDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, United States.
Dave HoweQuantitative Preclinical and Clinical Sciences Department, Praedicare Inc., Dallas, TX, United States.
Lesibana MalingaDepartment of Internal Medicine, University of Pretoria, Pretoria, South Africa.
Prithvi RajDepartment of Immunology, UT Southwestern Medical Center, Dallas, TX, United States.
Jan-Willem AlffenaarFaculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW, Australia.
Tawanda GumboQuantitative Preclinical and Clinical Sciences Department, Praedicare Inc., Dallas, TX, United States.
The University of Texas Southwestern Medical Center · USThe University of Sydney · AUUniversity of Cape Town · ZAUniversity of Pretoria · ZAUniversity of Virginia · US

Funding

PK/PD Optimized Cephalosporins Based Treatment Regimens for Children With MDR-TBR01HD099756 · NICHD · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI KANT, SHASHI · 2019 to 2023
$1.6M
NICHD NIH HHS R01 HD099756
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

avibactamcephalosporinshollow fiber modelmulti-drug resistancepharmacokinetics/pharmacodynamics

Identifiers

PMID34163361
PMCPMC8215380
OpenAlexW3168035157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.