ArticleJournal of pain research2021
Combined T2 Mapping and Diffusion Tensor Imaging: A Sensitive Tool to Assess Myofascial Trigger Points in a Rat Model.
Article in Journal of pain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 7 citations in OpenAlex.
- Inhibition of the AMPK/PGC-1α/Mfn2 Axis is Associated with Mitochondria-ER Dysfunction and Ultrastructural Remodeling in a Rat Model of Myofascial Trigger Points.Journal of pain research · 2026Article
- Quantifying structural properties of forearm flexor muscles in individuals with hemiparetic cerebral palsy using diffusion tensor imaging.Physiological reports · 2025Article
- Quantitative evaluation of therapeutic effect of silver needle thermal conduction therapy on myofascial trigger point.PloS one · 2025Article
- A clinical study of ultrasound-guided acupotomy combined with mindfulness meditation to improve lumbar myofascial pain syndrome.Frontiers in neurology · 2025Article
- Engeletin alleviates depressive-like behaviours by modulating microglial polarization via the LCN2/CXCL10 signalling pathway.Journal of cellular and molecular medicine · 2024Article
- Assessment of the Effects of Sphingosine Kinase 1/Sphingosine-1-Phosphate on Microangiogenesis at Rat Myofascial Trigger Points Using Contrast-Enhanced Ultrasonography.Journal of pain research · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMyofascial trigger points (MTrPs) are defined as very small and hypersensitive points in skeletal muscle that are palpable, and produce localized pain on compression. The aim of this study was to explore the feasibility of combining T2 mapping with diffusion tensor imaging (DTI) for assessing MTrPs in a rat model and to investigate properties of the pathophysiological mechanisms.
methodsTwenty-four Sprague-Dawley rats (model group, n = 14; control group, n = 10) underwent a magnetic resonance imaging (MRI) examination on a 3 T-MRI-scanner with a protocol consisting of T2 mapping and DTI. The MTrPs were established by blunt strike in combination with eccentric exercise. Enzyme-linked immunosorbent assays (ELISAs) were used to detect the levels of interleukin-1ß (IL-1ß) and interleukin-2 (IL-2) and their results were correlated with T2 values. Parameters from MRI including T2 values, fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) were compared between the two groups. Histological analysis was applied to provide an additional supply for MRI findings.
resultsThe MTrPs of rats displayed significantly increased T2 values and FA (= 0.000) compared with normal controls, whereas MD and RD values were significantly lower (
conclusionCombining T2 and DTI sequences creates a sensitive tool to assess MTrPs in a rat model. These data clarify a hypothesis that a trigger point is a chronic and mild muscle injury with inflammation.
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