ReviewClinical, cosmetic and investigational dermatology2021
The Impact of Acne, Atopic Dermatitis, Skin Toxicities and Scars on Quality of Life and the Importance of a Holistic Treatment Approach.
Review in Clinical, cosmetic and investigational dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07488988 (SCARFREE-001), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SCARFREE-001: A Phase 2 Dose-Finding and Proof-of-Concept Study of Intradermal Verteporfin for Scar Prevention in Open and Closed Surgical Wounds
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Lasers for the treatment of erythema, dyspigmentation, and decreased elasticity in macular acne scars: a systematic review.Lasers in medical science · 2022Pooled it
- Combined Effect of Microneedling and Platelet-Rich Plasma for the Treatment of Acne Scars: A Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Reassurance through normalization inadvertently suppresses treatment.Nature human behaviour · 2026Article
- Patient-Reported Experiences in Chronic Dermatological Conditions: Validation of the Romanian PSPSQ 2.0 Within Contemporary Dermatologic Care Pathways.Diagnostics (Basel, Switzerland) · 2026Article
- A Possible Role of Mycobiome in the Pathophysiology of Acne: Structured Narrative Review and Perspectives.Experimental dermatology · 2026Review
- Prevalence of Acne and Its Impact on Quality of Life, Social Appearance Anxiety and Treatment Practices Among Young Adults.Journal of cosmetic dermatology · 2026Article
- Topical β-Caryophyllene for Dermatologic Disorders: Mechanisms, Human Evidence, and Clinical Translation.Pharmaceuticals (Basel, Switzerland) · 2025Review
- A dual encoder network with multiscale feature fusion and multiple pooling channel spatial attention for skin scar image segmentation.Scientific reports · 2025Article
- Chitosan membranes incorporating Aloe vera glycolic extract with joint synthesis of silver nanoparticles for the treatment of skin lesions.Drug delivery and translational research · 2025Article
- Integrative Treatment Approaches with Mind-Body Therapies in the Management of Atopic Dermatitis.Journal of clinical medicine · 2024Review
- The role of dermocosmetics in the management of cancer-related skin toxicities: international expert consensus.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Review
- Dietary Patterns in Acne and Rosacea Patients-A Controlled Study and Comprehensive Analysis.Nutrients · 2023Article
- Enhanced Deep Learning Approach for Accurate Eczema and Psoriasis Skin Detection.Sensors (Basel, Switzerland) · 2023Article
- Estrogen alleviates acute and chronic itch in mice.Experimental and therapeutic medicine · 2023Article
- Development of Adapalene Loaded Liposome Based Gel for Acne.Gels (Basel, Switzerland) · 2023Article
- Advocacy for a shared physician/patient approach for the management of acne, rosacea, seborrheic dermatitis and photodamage.European journal of dermatology : EJD · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin conditions such as acne, atopic dermatitis, skin toxicity from oncology treatment, and scars are among the most common health conditions and negatively impact quality of life (QoL). Yet the physician perception of this impact often varies greatly from the patient perception. This is important because patient illness perception is closely linked with seeking help and treatment adherence behaviors. The objective of this review is to better understand the impact of these four highly prevalent skin conditions on QoL including their health-related economic factors to improve treatment outcomes. The literature search included literature published on QoL with acne, atopic dermatitis, scars (from any cause) and skin toxicities on PubMed between 2015 and 2020. We found that patients with skin conditions have a much higher frequency of altered QoL and psychological distress than those without. Also, skin conditions negatively impact self-image and can cause feelings of isolation, loneliness, lower self-esteem, and lower body satisfaction. Additionally, physical discomfort adds to the psychological distress. These physical and psychological impacts are an enormous financial burden on patients, their families and society. We found evidence that holistic treatment including treating the skin condition itself, providing wider peer and psychological support as well as shared decision-making, therapeutic patient education and dermatologist involvement improves outcomes. Holistic history-taking, checklists, or the use of more formal QoL scoring tools can be incorporated into routine consultations to better assess patient well-being and provide clinicians with important information for adapting treatment to individual patient requirements. In conclusion, this review highlights the overall impact of skin conditions (including psychological and QoL impacts) and the importance of providing holistic care to optimize treatment outcomes. A comprehensive QoL screening tool would be useful to help provide patient-centered treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.