Evidence map›Paper›PMID 34163197›Full record

ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2021

Current Practices and Gaps in Management of Dyslipidemia in Type 2 Diabetes Mellitus (T2DM) in Accordance with American Diabetes Association (ADA) Guidelines: A Subset Analysis from a Real-World, Cross-Sectional Observational Study (LEADD Study).

Ashok Kumar Das, Banshi Saboo, Ambika G Unnikrishnan

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Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

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12citing papers in PubMed
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12 citing papers in PubMed.

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5 · Who and what money

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3 authors.

Ashok Kumar DasDepartment of Endocrinology, Pondicherry Institute of Medical Sciences, Pondicherry, India.
Banshi SabooDepartment of Endocrinology, Dia Care, Ahmedabad, Gujarat, India.
Ambika G UnnikrishnanDepartment of Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic dyslipidemia is a risk factor for coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). American Diabetes Association (ADA) provides internationally accepted guidelines to manage dyslipidemia in T2DM.

objectiveTo assess if ADA guidelines are followed for managing dyslipidemia in patients with T2DM in India.

methodsThis was a subset analysis of a prospective, cross sectional, observational study (LEADD Study) conducted at 199 sites across India to evaluate dyslipidemia management practices in T2DM patients (N=4002), in a real-world setting. The data was stratified based on age and atherosclerotic cardiovascular disease (ASCVD) and ASCVD risk factors to record the percentages of T2DM patients achieving LDL-C target and treated optimally with the Guideline directed intensity of statin. Analysis was conducted using descriptive statistics.

resultsAs per ADA 2018 targets: LDL-C levels (<100mg/dL) were seen in 30.6% of participants. High intensity statins were prescribed to 13.4% of the participants with LDL levels ≥100 mg/dL. ASCVD risk assessment details were available for 89.2% of participants. Data was not available for smoking and albuminuria. In participants <40 years of age, 80% and 64.2% with ASCVD and ASCVD risk factors, respectively, did not achieve target LDL-C levels. In this age group, 15.6% and 83.3% of participants with ASCVD risk factors and ASCVD group, respectively, were not receiving statins in the recommended dose. In participants ≥40 years of age, 88.0% and 91.5% with ASCVD and ASCVD risk factors, respectively, did not have LDL-C levels as per ADA 2018 targets. In this age group, 87.2% and 77.9% of participants with ASCVD risk factors and ASCVD, respectively, were not receiving statins in the recommended dose.

conclusionThe sub-analysis of LEADD study shows sub-optimal adherence to ADA 2018 guidelines for management of diabetic dyslipidemia.

Indexed as

abnormal lipid profile in diabetesdiabetic dyslipidemiadyslipidemia in diabeteshypercholesteremia in diabeteshyperlipidemia in diabetes

Identifiers

PMID34163197
PMCPMC8214520

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