Evidence map›Paper›PMID 34163121›Full record

ReviewWorld journal of gastroenterology2021

Local ablation of pancreatic tumors: State of the art and future perspectives.

Vincenza Granata, Roberta Grassi, Roberta Fusco, Andrea Belli, Raffaele Palaia, Gianpaolo Carrafiello, Vittorio Miele, Roberto Grassi, Antonella Petrillo, Francesco Izzo

Open access · greenAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 41 citations in OpenAlex.

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  9. Reversible electroporation for cancer therapy.The British journal of radiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Vincenza GranataDepartment of Radiology, Istituto Nazionale Tumori -IRCCS- Fondazione G. Pascale, Naples 80131, Italy.
Roberta GrassiDepartment of Radiology, Università degli Studi della Campania Luigi Vanvitelli, Naples 80127, Italy.
Roberta FuscoDepartment of Radiology, Istituto Nazionale Tumori -IRCCS- Fondazione G. Pascale, Naples 80131, Italy. r.fusco@istitutotumori.na.it.
Andrea BelliDepartment of Surgery, Istituto Nazionale Tumori -IRCCS- Fondazione G. Pascale, Naples 80131, Italy.
Raffaele PalaiaDepartment of Surgery, Istituto Nazionale Tumori -IRCCS- Fondazione G. Pascale, Naples 80131, Italy.
Gianpaolo CarrafielloDepartment of Surgery, Università degli Studi di Milano, Milano 20122, Italy.
Vittorio MieleItalian Society of Medical and Interventional Radiology SIRM, SIRM Foundation Milan 20122, Italy.
Roberto GrassiDepartment of Radiology, Università degli Studi della Campania Luigi Vanvitelli, Naples 80127, Italy.
Antonella PetrilloDepartment of Radiology, Istituto Nazionale Tumori -IRCCS- Fondazione G. Pascale, Naples 80131, Italy.
Francesco IzzoDepartment of Surgery, Istituto Nazionale Tumori -IRCCS- Fondazione G. Pascale, Naples 80131, Italy.
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of Campania "Luigi Vanvitelli" · ITSocietà Italiana di Reumatologia · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently, the technologies most commonly used to treat locally advanced pancreatic cancer are radiofrequency ablation (RFA), microwave ablation, and irreversible (IRE) or reversible electroporation combined with low doses of chemotherapeutic drugs.

aimTo report an overview and updates on ablative techniques in pancreatic cancer.

methodsSeveral electronic databases were searched. The search covered the years from January 2000 to January 2021. Moreover, the reference lists of the found papers were analysed for papers not indexed in the electronic databases. All titles and abstracts were analysed.

resultsWe found 30 studies (14 studies for RFA, 3 for microwave therapy, 10 for IRE, and 3 for electrochemotherapy), comprising 1047 patients, which were analysed further. Two randomized trials were found for IRE. Percutaneous and laparotomy approaches were performed. In the assessed patients, the median maximal diameter of the lesions was in the range of 2.8 to 4.5 cm. All series included patients unfit for surgical treatment, but Martin

conclusionIn the management of patients with pancreatic cancer, the possibility of a multimodal approach should be considered, and conceptually, the combination of RFA with immunotherapy represents a novel angle of attack against this tumour.

Indexed as

Ablation TechniquesCatheter AblationPancreatic NeoplasmsRadiofrequency AblationElectroporationHumansPancreasAblation treatmentElectrochemotherapyIrreversibleMicrowave ablationPancreatic cancerRadiofrequency ablation

Identifiers

PMID34163121
PMCPMC8218359
OpenAlexW3174355296

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.