Trial reportNature2021
Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans.
Registry-linked trialAbstract readClinical Trial
In one paragraph
Trial report in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06395324 (Fiber Effectively Educates & Directs the Microbiome Study), which is not on this map. Cited by 74 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fiber Effectively Educates & Directs the Microbiome Study
Who cites it
74 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules.Cell host & microbe · 2025Pooled it
- Factors affecting dysbiosis of the gut microbiota in the elderly and the progress of interventions in traditional Chinese and Western medicine.Frontiers in cellular and infection microbiology · 2025Pooled it
- Cardiometabolic and molecular adaptations to 6-month intermittent fasting in middle-aged men and women with overweight: secondary outcomes of a randomized controlled trial.Nature communications · 2025Trial
- Donor composition and fiber promote strain engraftment in a randomized controlled trial of fecal microbiota transplant for ulcerative colitis.Med (New York, N.Y.) · 2025Trial
- A microbiome-directed therapeutic food for children recovering from severe acute malnutrition.Science translational medicine · 2024Trial
- Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota.Nature metabolism · 2024Trial
- Trial
- Effects of nutritional therapy on gastrointestinal microbial digestion and barrier defense markers in elderly patients with diabetes.Aging clinical and experimental research · 2023Trial
- CompBio and MIRaS-a multi-omic analysis platform built on a memory-based intelligence engine.Nucleic acids research · 2026Article
- Animal-associated jumbo phages as widespread and active modulators of gut microbiome ecology and metabolism.Science advances · 2026Article
- Quantitative susceptibility mapping demonstrates ageing-related long-term structural brain changes in adult rats after mild ischaemic stroke.Brain communications · 2026Article
- Identifying the causal relationship between gut microbiota and lymphoma disease: a Mendelian randomization study and meta-analysis.Archives of medical science : AMS · 2026Article
- Potential mechanisms by which microbiota-accessible carbohydrates regulate hepatic lipid metabolism in MAFLD via the gut-liver axis.Frontiers in microbiology · 2026Review
- Statistical design of a synthetic microbiome that suppresses diverse gut pathogens.bioRxiv : the preprint server for biology · 2025Article
- Precision microbiota therapy for IBD: premise and promise.Gut microbes · 2025Review
- Microbiota-mediated mechanisms of mucosal immunity across the lifespan.Nature immunology · 2025Review
- Fecal microbiomes from healthy adult consumers of fruits and vegetables exhibit fiber- and donor-specific fermentation: "5 a day" is not enough.Food & function · 2025Article
- A prevalent huge phage clade in human and animal gut microbiomes.bioRxiv : the preprint server for biology · 2025Article
- Advanced Modification Strategies of Plant-Sourced Dietary Fibers and Their Applications in Functional Foods.Foods (Basel, Switzerland) · 2025Review
- Subspecies phylogeny in the human gut revealed by co-evolutionary constraints across the bacterial kingdom.Cell systems · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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Authors and funding
25 authors.
Omar Delannoy-BrunoEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-6637-4609
Chandani DesaiEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-3708-3634
Arjun S RamanEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Robert Y ChenEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Matthew C HibberdEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-6520-677X
Jiye ChengEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-0266-3997
Nathan HanEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Juan J CastilloDepartment of Chemistry, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0001-9680-5273
Garret CoutureDepartment of Chemistry, University of California, Davis, CA, USA.
Carlito B LebrillaDepartment of Chemistry, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0001-7190-5323
Ruteja A BarveDepartment of Genetics, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-1171-9761
Vincent LombardArchitecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique and Aix-Marseille Université, Marseille, France.ORCID http://orcid.org/0000-0002-9684-7067
Bernard HenrissatArchitecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique and Aix-Marseille Université, Marseille, France.ORCID http://orcid.org/0000-0002-3434-8588
Semen A LeynInfectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9886-9120
Dmitry A RodionovInfectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Andrei L OstermanInfectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
David K HayashiMondelēz Global LLC, Chicago, IL, USA.
Alexandra MeynierMondelēz Global LLC, Chicago, IL, USA.
Sophie VinoyMondelēz Global LLC, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-1038-6985
Kyleigh KirbachDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Tara WilmotDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Samuel KleinDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Michael J BarrattEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Jeffrey I GordonEdison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA. jgordon@wustl.edu.ORCID http://orcid.org/0000-0001-8304-3548
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MTRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4MTrace the flow of genes in the gut microbiome of obese and lean twin pairsP01DK078669 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I · 2007 to 2018
$16.0MGUT MICROBIOTA AND OBESITY: STUDIES IN GNOTOBIOTIC MICER01DK070977 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I, HETTICH, ROBERT L. · 2005 to 2020
$6.3MMAXIMIZING STUDENT DIVERSITY IN THE BIOMEDICAL SCIENCES AT WASHINGTON UNIVERSITYR25GM103757 · NIGMS · WASHINGTON UNIVERSITY · PI SKEATH, JAMES BENJAMIN · 2013 to 2022
$4.5MWUSTL Transdisciplinary Pre- and Postdoctoral Training Program in Obesity and Cardiovascular DiseaseT32HL130357 · NHLBI · WASHINGTON UNIVERSITY · PI WILFLEY, DENISE ELLA · 2016 to 2025
$4.3MAnnotating carbohydrate structures to develop markers for consumption of foodR01DK124193 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEBRILLA, CARLITO B, LEMAY, DANIELLE GUYANNE · 2020 to 2024
$2.9MUnraveling the biological state of children with Environmental enteric dysfunctionF30DK124967 · NIDDK · WASHINGTON UNIVERSITY · PI CHEN, ROBERT YUZEN · 2020 to 2022
$115kNCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NHLBI NIH HHS T32 HL130357NIDDK NIH HHS F30 DK124967NIDDK NIH HHS P01 DK078669NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK070977NIDDK NIH HHS R01 DK124193NIGMS NIH HHS R25 GM103757NIGMS NIH HHS T32 GM007067NIH HHS DK078669NIH HHS DK70977
Abstract
Changing food preferences brought about by westernization that have deleterious health effects
Indexed as
Germ-Free LifeSnacksAdolescentAdultAnimalsBacteroidesBlood ProteinsDietary FiberFecesFemaleGastrointestinal MicrobiomeHumansMaleMiceMice, Inbred C57BLMiddle AgedBlood ProteinsDietary FiberProteome
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT06395324ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.