ArticleNature2021
A transcriptional switch governs fibroblast activation in heart disease.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.
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140citing papers in PubMed
12.5field-weighted citation impact, top 1% of its field
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Who cites it
140 citing papers in PubMed, 216 citations in OpenAlex.
- Mechanical stretch reduces fibroblast activation in heart failure with reduced ejection fraction.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026Article
- Cardiac unloading models for myocardial reverse remodeling.Basic research in cardiology · 2026Review
- Cell Type-Specific Roles for BRD4 in Heart Failure.Current cardiology reports · 2026Review
- Injection site dictates the immune response to a biodegradable polymer and corresponding collagen regeneration.Bioactive materials · 2026Article
- Cardiac fibroblast diversity in HFpEF: states, niches, interorgan drivers and targets.Nature reviews. Cardiology · 2026Review
- Genome folding and nuclear speckles converge to orchestrate fibroblast activation.Science advances · 2026Article
- Cerebrovascular vulnerability and fibrosis in human brain aneurysms.Nature neuroscience · 2026Article
- Next-generation molecular imaging of cardiac fibrosis.The international journal of cardiovascular imaging · 2026Review
- Ubiquitin-Related Proteostatic Programs in Cycling Fibroblast-Lineage Remodeling After Myocardial Ischemic Injury: A Hypothesis Informed by Single-Cell and Spatial Transcriptomics.International journal of molecular sciences · 2026Review
- Unleashing innovative cross-organ fibrosis therapies by harnessing the omics revolution.JCI insight · 2026Review
- Epicardial Contributions to Fibro-Inflammatory Signaling in a Pkp2-Deficient Arrhythmogenic Cardiomyopathy Model.Circulation. Heart failure · 2026Article
- Conserved Transcriptional Circuits Regulate Cardiac Fibroblast-Mediated Fibrosis.Circulation research · 2026Article
- Macropinocytosis inhibition attenuates profibrotic responses in lung fibroblasts and pulmonary fibrosis models.The Journal of clinical investigation · 2026Article
- Cardiac fibroblasts in myocardial injury and heart failure.European heart journal · 2026Review
- MEOX1 Inhibits Growth and Metastasis of Salivary Adenoid Cystic Carcinoma.Current issues in molecular biology · 2026Article
- Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities.MedComm · 2026Review
- Cardiac epigenome in heart development and disease.Nature reviews. Cardiology · 2026Review
- CAR-T cells targeting fibroblast activation protein eliminate pathological fibroblasts and preserve cardiac function in a Duchenne Muscular Dystrophy murine model.Stem cell research & therapy · 2026Article
- The impact of inflammation, neuromodulation, and gut microbiota on developing cardiac fibrosis and hypertension.Cardiovascular research · 2026Review
- Programming the beating heart with polymer catalysis: a therapeutic microenvironment revolution.Journal of nanobiotechnology · 2026Review
80 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors at 5 institutions in 1 country.
Michael AlexanianGladstone Institutes, San Francisco, CA, USA.
Pawel F PrzytyckiGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3360-6936
Rudi MichelettiHoward Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Arun PadmanabhanGladstone Institutes, San Francisco, CA, USA.
Lin YeGladstone Institutes, San Francisco, CA, USA.
Joshua G TraversDepartment of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-5660-2620
Barbara Gonzalez-TeranGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4336-8644
Ana Catarina SilvaGladstone Institutes, San Francisco, CA, USA.
Qiming DuanGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6204-3028
Sanjeev S RanadeGladstone Institutes, San Francisco, CA, USA.
Franco FelixGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4297-7149
Ricardo Linares-SaldanaCardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2657-825X
Li LiCardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Clara Youngna LeeGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9402-4155
Nandhini SadagopanGladstone Institutes, San Francisco, CA, USA.
Angelo PeloneroGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-7684-3771
Yu HuangGladstone Institutes, San Francisco, CA, USA.
Gaia AndreolettiInstitute for Computational Health Sciences, University of California, San Francisco, CA, USA.
Rajan JainCardiovascular Institute and Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Timothy A McKinseyDepartment of Medicine, Division of Cardiology and Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Michael G RosenfeldHoward Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Casey A GiffordGladstone Institutes, San Francisco, CA, USA.
Katherine S PollardGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9870-6196
Saptarsi M HaldarGladstone Institutes, San Francisco, CA, USA. saptarsi.haldar@gladstone.ucsf.edu.ORCID http://orcid.org/0000-0001-7968-9696
Deepak SrivastavaGladstone Institutes, San Francisco, CA, USA. deepak.srivastava@gladstone.ucsf.edu.ORCID http://orcid.org/0000-0002-3480-5953
Gladstone Institutes · USCardiovascular Institute of the South · USHoward Hughes Medical Institute · USUniversity of Colorado Anschutz Medical Campus · USUniversity of California, San Francisco · US
Funding
Transcriptional Networks During Cardiac DifferentiationP01HL089707 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI SRIVASTAVA, DEEPAK · 2008 to 2017
$20.4MCARDIOGENESIS--MOLECULAR MECHANISMSR01HL057181 · NHLBI · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI DEEPAK SRIVASTAVA · 1997 to 2026
$14.0MProject 3: Control of cardiac transcription by MEF2 and myocardinP01HL146366 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI SRIVASTAVA, DEEPAK · 2019 to 2023
$13.7MThe Epigenetic Landscape of Heart DevelopmentU01HL098179 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BOYER, LAURIE A, BRUNEAU, BENOIT GAETAN · 2009 to 2014
$10.0MRegulation of Chromatin Signaling in Heart Failure by the BRD4 Bromodomain Protein.R01HL127240 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MCKINSEY, TIMOTHY, SRIVASTAVA, DEEPAK · 2015 to 2022
$6.4MThe Epigenetic Landscape of Heart DevelopmentUM1HL098179 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN, POLLARD, KATHERINE S. · 2015 to 2019
$4.7MDeacetylase-Dependent Control of Diastolic Dysfunction and HFpEFR01HL147558 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HOUSER, STEVEN R, MCKINSEY, TIMOTHY · 2019 to 2022
$3.1MRegulation of Cardiac Signaling by Class I Histone DeacetylasesR01HL116848 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MCKINSEY, TIMOTHY · 2013 to 2021
$3.1MSmall molecule therapies targeting chromatin architecture in heart failureR01HL150225 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCKINSEY, TIMOTHY, VONDRISKA, THOMAS M. · 2020 to 2023
$2.9MA stress-induced promoter pause release program in cardiomyocytes protecting against myocardial infarctionR01HL150521 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 2020 to 2023
$2.7MAortic Valve Disease: Mechanisms and Therapeutic ApproachesR01HL150100 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI SRIVASTAVA, DEEPAK · 2020 to 2023
$2.7MResolving single-cell brain regulatory elements with bulk data supervised modelsR01MH123178 · NIMH · J. DAVID GLADSTONE INSTITUTES · PI POLLARD, KATHERINE S. · 2020 to 2023
$2.4MAHRQ HHS R01 HS015100NCRR NIH HHS C06 RR018928NHLBI NIH HHS F32 HL147463NHLBI NIH HHS K08 HL157700NHLBI NIH HHS P01 HL089707NHLBI NIH HHS P01 HL146366NHLBI NIH HHS R01 HL057181NHLBI NIH HHS R01 HL116848NHLBI NIH HHS R01 HL127240NHLBI NIH HHS R01 HL139783NHLBI NIH HHS R01 HL147558NHLBI NIH HHS R01 HL150100NHLBI NIH HHS R01 HL150225NHLBI NIH HHS R01 HL150521NHLBI NIH HHS U01 HL098179NHLBI NIH HHS UM1 HL098179NIDDK NIH HHS R01 DK119594NIMH NIH HHS R01 MH123178
Abstract
In diseased organs, stress-activated signalling cascades alter chromatin, thereby triggering maladaptive cell state transitions. Fibroblast activation is a common stress response in tissues that worsens lung, liver, kidney and heart disease, yet its mechanistic basis remains unclear
Indexed as
Enhancer Elements, GeneticAnimalsBromodomain Containing ProteinsChromatinEpigenomicsFibroblastsGene Expression RegulationHeart DiseasesHomeodomain ProteinsHumansMiceProteinsSingle-Cell AnalysisTranscription FactorsTranscriptomeTransforming Growth Factor betabromodomain and extra-terminal domain protein, humanBromodomain Containing ProteinsChromatinHomeodomain ProteinsMEOX1 protein, humanMeox1 protein, mouseProteinsTranscription FactorsTransforming Growth Factor beta
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