ArticleCommunications biology2021
Multiomic analysis of the Arabian camel (Camelus dromedarius) kidney reveals a role for cholesterol in water conservation.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 21 citations in OpenAlex.
- A clinical and experimental investigation of liraglutide effects on the brain-kidney axis.Science advances · 2026Article
- Transcriptomic changes in the jerboa supraoptic nucleus during osmotic stress: PCSK1 and PTPRN changes are conserved across desert and mesic species.Journal of neuroendocrinology · 2026Article
- Effect of melatonin supplementation on sperm quality in dromedary camel (Camelus dromedarius) under physiological and short-term cold storage conditions.Tropical animal health and production · 2026Article
- Dehydration promotes intracellular lipid synthesis and accumulation.Nature communications · 2026Article
- Metabolomic Profiling and Bioactivity Assessment of Moroccan Camel Urine: Antioxidant Activity and Preliminary Phage-Based Screening.Chemistry & biodiversity · 2026Article
- Article
- Evaluation of genetic studies on camels in Saudi Arabia: traits, tools, and applications.Tropical animal health and production · 2026Review
- INSIG1 parallel substitution drives lipid/sterol metabolic plasticity mediating desert adaptation in ungulates.Communications biology · 2026Article
- Long-term ultrasound insights into camelid urology: a retrospective analysis of urinary tract disorders in 1,100 dromedary camels (Frontiers in veterinary science · 2026Article
- Reconstruction of the transcriptional regulatory networks in the kidney of desert-adapted species.Communications biology · 2025Article
- Multiomic Analyses Reveal the Molecular Mechanisms of Arid Adaptation in a Desert Rodent Species.Molecular biology and evolution · 2025Article
- Genomic insights into the convergent evolution of desert adaptation in camels and antelopes.Zoological research · 2025Article
- Deciphering genetic adaptations of Old World camels through comparative genomic analyses across all camelid species.iScience · 2025Article
- Differentially Expressed Genes in Cardiomyocytes of the First Camelized Mouse Model, NrapGenes · 2025Article
- Effects of long-term dehydration and quick rehydration on the camel kidney: pathological changes and modulation of the expression of solute carrier proteins and aquaporins.BMC veterinary research · 2024Article
- Integration analysis of pituitary proteome and transcriptome reveals fertility-related biomarkers inFrontiers in endocrinology · 2024Article
- Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration.iScience · 2023Article
- Effects of long-term dehydration on stress markers, blood parameters, and tissue morphology in the dromedary camel (Frontiers in veterinary science · 2023Article
- Sex Differences in Fecal Microbiome Composition and Function of Dromedary Camels in Saudi Arabia.Animals : an open access journal from MDPI · 2022Article
- Transcriptomic plasticity of the hypothalamic osmoregulatory control centre of the Arabian dromedary camel.Communications biology · 2022Article
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
The Arabian camel (Camelus dromedarius) is the most important livestock animal in arid and semi-arid regions and provides basic necessities to millions of people. In the current context of climate change, there is renewed interest in the mechanisms that enable camelids to survive in arid conditions. Recent investigations described genomic signatures revealing evolutionary adaptations to desert environments. We now present a comprehensive catalogue of the transcriptomes and proteomes of the dromedary kidney and describe how gene expression is modulated as a consequence of chronic dehydration and acute rehydration. Our analyses suggested an enrichment of the cholesterol biosynthetic process and an overrepresentation of categories related to ion transport. Thus, we further validated differentially expressed genes with known roles in water conservation which are affected by changes in cholesterol levels. Our datasets suggest that suppression of cholesterol biosynthesis may facilitate water retention in the kidney by indirectly facilitating the AQP2-mediated water reabsorption.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.