ArticleScientific reports2021
Quantitative not qualitative histology differentiates aneurysmal from nondilated ascending aortas and reveals a net gain of medial components.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Meta-analysis of the histopathological features of surgically removed aortas classified according to the SCVP and AECVP consensus documents.American heart journal plus : cardiology research and practice · 2026Article
- Hypertension drives thoracic aortic aneurysm and dissection in male, but not female, Marfan mice.Journal of the mechanical behavior of biomedical materials · 2026Article
- Hydraulic fracturing-induced delamination and extravasation extends medial damage beyond the false lumen in aortic dissection.bioRxiv : the preprint server for biology · 2026Article
- Increased medial collagen enhances aortic resilience against mural delamination from hydraulic fracturing.bioRxiv : the preprint server for biology · 2026Article
- Pseudocoarctation-associated aneurysm in a young female: surgical resection and histological evidence of aortic fragility with five-year surveillance.Journal of cardiothoracic surgery · 2026Article
- Improved hemodynamic and cardiorespiratory instability with vitamin D supplementation in an obstructive sleep apnea rat models.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2026Article
- Quantitative Histomorphometric Analysis of Collagen Bundles in Masson's Trichrome Stained Rat (Health science reports · 2026Article
- Loss of wall stress homeostasis in ascending thoracic aortic aneurysm: histomorphometric insights into patient variants.The Journal of physiology · 2025Article
- A multiphasic model for determination of mouse ascending thoracic aorta mass transport properties with and without aneurysm.Biomechanics and modeling in mechanobiology · 2025Article
- Baseline Diameter Does Not Predict Growth Rate in a Presurgical Ascending Thoracic Aortic Aneurysm Population.Journal of the American Heart Association · 2024Article
- TheFrontiers in cardiovascular medicine · 2024Article
- Mapping microarchitectural degeneration in the dilated ascending aorta withEuropean heart journal open · 2024Article
- Lengthwise regional mechanics of the human aneurysmal ascending thoracic aorta.Acta biomaterialia · 2023Article
- Morphological Features of the Ascending Aorta Remodeling and Activation of Regeneratory Potential in Intima when Forming Aneurysm.Bulletin of experimental biology and medicine · 2023Article
- Medial degeneration and atherosclerosis show discrete variance around the circumference of ascending aorta aneurysms.Virchows Archiv : an international journal of pathology · 2022Article
- Exploring the Effect and Mechanism of Si-Miao-Yong-An Decoction on Abdominal Aortic Aneurysm Based on Mice Experiment and Bioinformatics Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
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Authors and funding
15 authors at 1 institution in 2 countries.
Funding
Abstract
Medial degeneration is a common histopathological finding in aortopathy and is considered a mechanism for dilatation. We investigated if medial degeneration is specific for sporadic thoracic aortic aneurysms versus nondilated aortas. Specimens were graded by pathologists, blinded to the clinical diagnosis, according to consensus histopathological criteria. The extent of medial degeneration by qualitative (semi-quantitative) assessment was not specific for aneurysmal compared to nondilated aortas. In contrast, blinded quantitative assessment of elastin amount and medial cell number distinguished aortic aneurysms and referent specimens, albeit with marked overlap in results. Specifically, the medial fraction of elastin decreased from dilution rather than loss of protein as cross-sectional amount was maintained while the cross-sectional number, though not density, of smooth muscle cells increased in proportion to expansion of the media. Furthermore, elastic lamellae did not thin and interlamellar distance did not diminish as expected for lumen dilatation, implying a net gain of lamellar elastin and intralamellar cells or extracellular matrix during aneurysmal wall remodeling. These findings support the concepts that: (1) medial degeneration need not induce aortic aneurysms, (2) adaptive responses to altered mechanical stresses increase medial tissue, and (3) greater turnover, not loss, of mural cells and extracellular matrix associates with aortic dilatation.
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