ArticleScientific reports2021
Crayfish hemocytes develop along the granular cell lineage.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 47 citations in OpenAlex.
- Dnmt1 mediates epigenetic restriction of invasive traits in clonal crayfish.Nature communications · 2026Article
- Pathogenic diversity ofCell surface (Amsterdam, Netherlands) · 2025Article
- Inducing bursicon expression using 20-hydroxyecdysone (20E) increased immune response in Macrobrachium rosenbergii against Aeromonas hydrophila.Biology open · 2025Article
- Longitudinal tracking of hemocyte populations in vivo indicates lineage relationships and supports neural progenitor identity in adult neurogenesis.Neural development · 2024Article
- scRNA-seq Analysis of Hemocytes of Penaeid Shrimp Under Virus Infection.Marine biotechnology (New York, N.Y.) · 2023Article
- A Straightforward Method for the Isolation and Cultivation ofInternational journal of molecular sciences · 2022Article
- Adult neurogenesis in crayfish: Identity and regulation of neural progenitors produced by the immune system.iScience · 2022Article
- Single-cell RNA-seq uncovered hemocyte functional subtypes and their differentiational characteristics and connectivity with morphological subpopulations inFrontiers in immunology · 2022Article
- Single cell RNA sequencing reveals hemocyte heterogeneity inFrontiers in immunology · 2022Article
- Time-Course of the Innate Immune Response of the Terrestrial CrustaceanFrontiers in immunology · 2022Article
- Recent insights into hematopoiesis in crustaceans.Fish and shellfish immunology reports · 2021Article
- Rapid regulation of hemocyte homeostasis in crayfish and its manipulation by viral infection.Fish and shellfish immunology reports · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the central role of hemocytes in crustacean immunity, the process of hemocyte differentiation and maturation remains unclear. In some decapods, it has been proposed that the two main types of hemocytes, granular cells (GCs) and semigranular cells (SGCs), differentiate along separate lineages. However, our current findings challenge this model. By tracking newly produced hemocytes and transplanted cells, we demonstrate that almost all the circulating hemocytes of crayfish belong to the GC lineage. SGCs and GCs may represent hemocytes of different developmental stages rather than two types of fully differentiated cells. Hemocyte precursors produced by progenitor cells differentiate in the hematopoietic tissue (HPT) for 3 ~ 4 days. Immature hemocytes are released from HPT in the form of SGCs and take 1 ~ 3 months to mature in the circulation. GCs represent the terminal stage of development. They can survive for as long as 2 months. The changes in the expression pattern of marker genes during GC differentiation support our conclusions. Further analysis of hemocyte phagocytosis indicates the existence of functionally different subpopulations. These findings may reshape our understanding of crustacean hematopoiesis and may lead to reconsideration of the roles and relationship of circulating hemocytes.
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