ArticleNature communications2021
Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
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- Enzyme-Activatable Fluorogenic Probes: Design Strategies, Biomedical Applications, and Future Perspectives.Journal of the American Chemical Society · 2026Review
- Three in one fluorescent sensing and imaging of chemical warfare agents.Nature communications · 2026Article
- Molecular rotor-based probes for protein monitoring in biomedical research.Nature reviews. Chemistry · 2026Review
- Difluoroboronated tetrazine probes for rapid bioorthogonal fluorescence activation, no-wash STED imaging, and triggered drug release.Science advances · 2025Article
- Aqueous up-conversion organic phosphorescence and tunable dual emission in a single-molecular emitter.Chemical science · 2025Article
- Excited-State-Altering Ratiometric Fluorescent Probes for the Response ofMolecules (Basel, Switzerland) · 2025Article
- Mitochondrial Electron Flow Dynamics Imaging for Assessing Mitochondrial Quality and Drug Screening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Tailoring Super-Performed Chemo-Sensor via Simulation-Modeling and MEMS-Screening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Near-Infrared Bioimaging Using Two-photon Fluorescent Probes.Advanced healthcare materials · 2025Review
- Ratiometric fluorescence probes for visible detection and accurate identification of MPEA vapor.Nature communications · 2024Article
- Visible Tracking of Small Molecules of Gases with Fluorescent Donors.Chemical & biomedical imaging · 2024Review
- Electrophilicity Modulation for Sub-ppm Visualization and Discrimination of EDA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A Reversible Dual-Channel Near-Infrared Flavonoid Probe forChemical & biomedical imaging · 2023Article
- Fluorescent Organic Small Molecule Probes for Bioimaging and Detection Applications.Molecules (Basel, Switzerland) · 2022Review
- NIR-II AIEgens with Photodynamic Effect for Advanced Theranostics.Molecules (Basel, Switzerland) · 2022Review
- 1Molecules (Basel, Switzerland) · 2022Review
- Article
- Sequence-Activated Fluorescent Nanotheranostics for Real-Time Profiling Pancreatic Cancer.JACS Au · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intramolecular charge transfer (ICT) is a fundamental mechanism that enables the development of numerous fluorophores and probes for bioimaging and sensing. However, the electron-withdrawing targets (EWTs)-induced fluorescence quenching is a long-standing and unsolved issue in ICT fluorophores, and significantly limits the widespread applicability. Here we report a simple and generalizable structural-modification for completely overturning the intramolecular rotation driving energy, and thus fully reversing the ICT fluorophores' quenching mode into light-up mode. Specifically, the insertion of an indazole unit into ICT scaffold can fully amplify the intramolecular rotation in donor-indazole-π-acceptor fluorophores (fluorescence OFF), whereas efficiently suppressing the rotation in their EWT-substituted system (fluorescence ON). This molecular strategy is generalizable, yielding a palette of chromophores with fluorescence umpolung that spans visible and near-infrared range. This strategy expands the bio-analytical toolboxes and allows exploiting ICT fluorophores for light-up sensing of EWTs including N-acetyltransferases and nerve agents.
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