ArticleNature communications2021
TCF21
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 56 citations in OpenAlex.
- Spatiotemporally primed coelomic epithelium and supporting-like cells establish the dual origin of granulosa cells.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Platelet-Derived Growth Factor Receptor Alpha in Male Reproductive Health and Oxidative Stress: Stromal Homeostasis, Injury, and Research Perspectives.Antioxidants (Basel, Switzerland) · 2026Review
- Review
- Multi-omic analysis of androgen-deprived human testes reveals Sertoli cell regulation and niche reprogramming.Nature communications · 2026Article
- Article
- Efficient differentiation of gonadal somatic cell-like cells (GSCLCs) using magnetic nanoparticles from mouse embryonic stem cells.American journal of translational research · 2026Article
- Article
- Ovarian development is driven by early spatiotemporal priming of the coelomic epithelium.bioRxiv : the preprint server for biology · 2025Article
- Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling.Scientific reports · 2025Article
- Generation of a Nr2f2-driven inducible Cre mouse to target interstitial cells in the reproductive system†.Biology of reproduction · 2025Article
- Dynamics of Cell Fate Decisions during Chemically Induced Multi-Lineage Trans-Differentiation at Single-Cell Level.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- NR2F2 regulation of interstitial cell fate in the embryonic mouse testis and its impact on differences of sex development.Nature communications · 2025Article
- GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model.Cell research · 2024Article
- Single-cell transcriptomic and cross-species comparison analyses reveal distinct molecular changes of porcine testes during puberty.Communications biology · 2024Article
- The single-cell chromatin landscape in gonadal cell lineage specification.BMC genomics · 2024Article
- Loss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility.Cellular and molecular life sciences : CMLS · 2024Article
- Stem Leydig cells support macrophage immunological homeostasis through mitochondrial transfer in mice.Nature communications · 2024Article
- A multi-omics analysis of viral nucleic acid poly(I:C) responses to mammalian testicular stimulation.Stress biology · 2024Article
- Effects of Leydig cell elimination on testicular interstitial cell populations: characterization by scRNA-seq and immunocytochemical techniques.Frontiers in endocrinology · 2024Article
- Analyzing the cellular and molecular atlas of ovarian mesenchymal cells provides a strategy against female reproductive aging.Science China. Life sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 1 country.
Yu-Chi Shen *Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1501-3528
Adrienne Niederriter Shami *Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Lindsay Moritz *Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA.
Hailey Larose *Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Gabriel L ManskeCellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA.
Qianyi MaDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Xianing ZhengDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Meena SukhwaniDepartment of Obstetrics, Gynecology and Reproductive Sciences, Integrative Systems Biology Graduate Program, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Michael CzerwinskiDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Caleb SultanDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Haolin ChenBiochemistry and Molecular Biology, Bloomberg School of Public Health, John Hopkins, USA.
Stephen J GurczynskiDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Jason R SpenceDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-7869-3992
Kyle E OrwigDepartment of Obstetrics, Gynecology and Reproductive Sciences, Integrative Systems Biology Graduate Program, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Michelle TallquistUniversity of Hawaii, Center for Cardiovascular Research, Honolulu, HI, USA.
Jun Z LiDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-6727-0812
Saher Sue HammoudDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA. hammou@med.umich.edu.ORCID 0000-0002-5040-6370
University of Michigan · USUniversity of Pittsburgh · USJohns Hopkins University · USUniversity of Hawaii System · US
Funding
MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3MCELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8MTRAINING PROGRAM IN ORGANOGENESIST32HD007505 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA, SPENCE, JASON · 1997 to 2021
$6.9MContributions of Sperm Chromatin to development: A Myth or Reality?DP2HD091949 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMMOUD, SAHER SUE · 2016 to 2016
$2.3MCareer Training in Reproductive BiologyT32HD079342 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Suzanne M MOENTER · 2014 to 2026
$2.3MRegulation of cardiac inflammation by fibroblastsR01HL144067 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI TALLQUIST, MICHELLE D · 2018 to 2021
$2.3MImproving Fertility Preservation in Boys with CancerR01HD092084 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ORWIG, KYLE EDWIN · 2017 to 2019
$1.1MComprehensive mapping of mouse testis cell types and spermatogenic stages by single-cell RNA sequencingR21HD090371 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMMOUD, SAHER SUE · 2018 to 2019
$444kThe Role of Parental Histone Proteins in Early DevelopmentF31HD100124 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MANSKE, GABRIEL LEE · 2019 to 2021
$113kElucidating the Role of TCF21+ Mesenchymal Cells in Testis Tissue Homeostasis and RegenerationF30HD097961 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAMI, ADRIENNE NIEDERRITER · 2018 to 2020
$108kNHLBI NIH HHS R01 HL144067NICHD NIH HHS DP2 HD091949NICHD NIH HHS F30 HD097961NICHD NIH HHS F31 HD100124NICHD NIH HHS R01 HD092084NICHD NIH HHS R21 HD090371NICHD NIH HHS T32 HD007505NICHD NIH HHS T32 HD079342NIGMS NIH HHS T32 GM007315NIGMS NIH HHS T32 GM007863
Abstract
Testicular development and function rely on interactions between somatic cells and the germline, but similar to other organs, regenerative capacity declines in aging and disease. Whether the adult testis maintains a reserve progenitor population remains uncertain. Here, we characterize a recently identified mouse testis interstitial population expressing the transcription factor Tcf21. We found that TCF21
Indexed as
AnimalsBasic Helix-Loop-Helix ProteinsCell DifferentiationCell LineageCells, CulturedFemaleGene Expression ProfilingHomeostasisLeydig CellsMaleMesenchymal Stem CellsMiceMice, Inbred C57BLMice, TransgenicRegenerationSingle-Cell AnalysisBasic Helix-Loop-Helix ProteinsTcf21 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.