Evidence map›Paper›PMID 34162854›Full record

ArticleNature communications2021

Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties.

Simon J Allison, Jaroslaw Bryk, Christopher J Clemett, Robert A Faulkner, Michael Ginger, Hollie B S Griffiths, Jane Harmer, P Jane Owen-Lynch, Emma Pinder, Heiko Wurdak and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
8.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
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  5. Article
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  7. Article
  8. Dynamic Covalent Self-Assembly of Chloride- and Ion-Pair-Templated Cryptates.Angewandte Chemie (International ed. in English) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Simon J AllisonSchool of Applied Sciences, University of Huddersfield Queensgate, Huddersfield, UK. s.allison@hud.ac.uk.ORCID http://orcid.org/0000-0002-5766-2377
Jaroslaw BrykSchool of Applied Sciences, University of Huddersfield Queensgate, Huddersfield, UK.
Christopher J ClemettSchool of Applied Sciences, University of Huddersfield Queensgate, Huddersfield, UK.ORCID http://orcid.org/0000-0001-7880-0743
Robert A FaulknerSchool of Applied Sciences, University of Huddersfield Queensgate, Huddersfield, UK.ORCID http://orcid.org/0000-0001-5361-3300
Michael GingerSchool of Applied Sciences, University of Huddersfield Queensgate, Huddersfield, UK.
Hollie B S GriffithsSchool of Applied Sciences, University of Huddersfield Queensgate, Huddersfield, UK.
Jane HarmerSchool of Applied Sciences, University of Huddersfield Queensgate, Huddersfield, UK.ORCID http://orcid.org/0000-0003-1247-4468
P Jane Owen-LynchSchool of Applied Sciences, University of Huddersfield Queensgate, Huddersfield, UK.ORCID http://orcid.org/0000-0002-5928-2327
Emma PinderSchool of Applied Sciences, University of Huddersfield Queensgate, Huddersfield, UK.ORCID http://orcid.org/0000-0001-9153-2341
Heiko WurdakSchool of Medicine, University of Leeds, Leeds, UK.
Roger M PhillipsSchool of Applied Sciences, University of Huddersfield Queensgate, Huddersfield, UK. r.m.phillips@hud.ac.uk.
Craig R RiceSchool of Applied Sciences, University of Huddersfield Queensgate, Huddersfield, UK. c.r.rice@hud.ac.uk.ORCID http://orcid.org/0000-0002-0630-4860
University of Huddersfield · GBUniversity of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One topical area of supramolecular chemistry is the binding of anionic species but despite the importance of anions in diverse cellular processes and for cancer development, anion receptors or 'binders' have received little attention as potential anti-cancer therapeutics. Here we report self-assembling trimetallic cryptands (e.g. [L

Indexed as

A549 CellsAnionsAntineoplastic AgentsAutophagyBlotting, WesternCell LineCell Line, TumorCell SurvivalCoordination ComplexesCrystallography, X-RayHCT116 CellsHT29 CellsHumansInhibitory Concentration 50MetalsNeoplasmsAnionsAntineoplastic AgentsCoordination ComplexesMetalsPhosphotransferases

Identifiers

PMID34162854
PMCPMC8222254
OpenAlexW3177238759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.