ReviewMedicina oral, patologia oral y cirugia bucal2021
Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper.
Review in Medicina oral, patologia oral y cirugia bucal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The correlation between human papillomavirus and oral lichen planus: A systematic review of the literature.Immunity, inflammation and disease · 2023Pooled it
- Significance of immunohistochemistry biomarkers in prediction of malignant transformation of oral lichen planus: A systematic review.Medicina oral, patologia oral y cirugia bucal · 2022Pooled it
- Curcumin in oral potentially malignant disorders and oral squamous cell carcinoma: Clinical and biological evidence from a systematic review.Journal of clinical and experimental dentistry · 2026Review
- Oral Lichen Planus and Oral Lichenoid Lesion in Pediatric Patients: A Narrative Review of Published Case Reports.Reports (MDPI) · 2026Review
- The Inflammatory-Dysplastic Spectrum in Oral Lichen Planus: A Study on Six Immunohistochemical Markers.Diagnostics (Basel, Switzerland) · 2025Article
- [Progress in clinicopathological diagnosis of oral potentially malignant disorders].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025Review
- Clinical and demographic profile of oral lichen planus in Sri Lanka: a retrospective study.European oral research · 2025Article
- Malignant transformation of oral lichen planus: where are we now?Medicina oral, patologia oral y cirugia bucal · 2025Review
- Demographic and clinicopathological comparison among oral lichen planus, lichenoid lesions and proliferative verrucous leukoplakia: a retrospective study.BMC oral health · 2024Observational
- Retrospective Analysis of Blood Inflammatory Biomarkers in Patients with Oral Lichen Planus: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio.Journal of clinical medicine · 2024Article
- Diagnostic potential of salivary IL-1β, IL-8, SAT, S100P, and OAZ1 in oral squamous cell carcinoma, oral submucous fibrosis, and oral lichen planus based on findings from a Sri Lankan cohort.Scientific reports · 2024Article
- DAPK-1 as a Potential Early Marker for Malignant Transformation Risk of Oral Lichen Planus.Cureus · 2024Article
- Review
- Direct immunofluorescence cannot be used solely to differentiate among oral lichen planus, oral lichenoid lesion, and oral epithelial dysplasia.Journal of dental sciences · 2023Article
- Salivary level of microRNA-146a and microRNA-155 biomarkers in patients with oral lichen planus versus oral squamous cell carcinoma.BMC oral health · 2023Article
- Early Diagnosis of Oral Cancer: A Complex Polyhedral Problem with a Difficult Solution.Cancers · 2023Review
- Review
- A Clinicohistopathological Characterization of Oral Lichen Planus: A Cross-Sectional Study.Cureus · 2022Article
- Langerhans Cells, T Cells, and B Cells in Oral Lichen Planus and Oral Leukoplakia.International journal of dentistry · 2022Article
- Comparison of CEA and IgG serum levels in oral lichenoid lesions before and after treatment with topical corticosteroids.Journal of dental research, dental clinics, dental prospects · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with oral lichen planus (OLP) have an increased risk of oral cancer. For this reason, OLP is classified as an oral potentially malignant disorder. However, the precise personal (or individual) risk is unknown. Recent meta-analytical studies have reported that dysplastic OLP may transform to cancer in around 6% of cases, while the rate of transformation is lower (<1.5%) in non-dysplastic cases. The presence of epithelial dysplasia has emerged as the most powerful indicator for assessing cancer risk in oral potentially malignant disorders in routine practice. However, the general acceptance of epithelial dysplasia as an accompanying histologic feature in OLP is subject to great controversy. Many pathologists consider the presence of dysplasia as a criterion to exclude OLP when routinely reporting on this disease. This practice, widespread among oral pathology professionals, has resulted in the underestimation of the potential for malignancy of OLP. MATERIAL AND
methodsA review of the literature was carried out in order to critically analyze the relevance, controversies and challenges encountered across the diagnosis of epithelial dysplasia in OLP.
results12 studies have been published examining dysplastic changes in OLP, reporting figures ranging from 0.54% to 25% of cases with dysplasia in the first diagnostic biopsy. The diagnosis of dysplasia in the OLP poses an additional difficulty due to the fact that the affected oral epithelium per se develops changes related to autoimmune aggression. Among the most frequent histological features of OLP that develops dysplasia are basal cell hyperplasia with basaloid appearance, loss of basal cells polarity, cellular and nuclear pleomorphism and irregular stratification.
conclusionsEpithelial dysplasia should not be considered an exclusion criterion for OLP; its evaluation requires experienced pathologists in this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.