ArticleScience advances2021
Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 65 citations in OpenAlex.
- Editorial: From causal circuit mapping to clinical translation: Prefronto-thalamic hypoconnectivity in schizophrenia.PCN reports : psychiatry and clinical neurosciences · 2026Article
- A prefrontal cortex-hypothalamus circuit for heart rate control in non-human primates.bioRxiv : the preprint server for biology · 2026Article
- Noninvasive focal gene transfer of chemogenetic proteins in the primate brain.Cell reports methods · 2026Article
- Working Memory as a Candidate Mechanism Linking Aging and the Sense of Agency: A Narrative Review.Brain sciences · 2026Review
- Advances in chemogenetics: a review of DREADDs and its application in psychiatric disorders.Molecular psychiatry · 2026Review
- Synaptic Silencing with Transactivation of Tetanus Neurotoxin for Pathway-Selective Manipulation.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Prefronto-thalamic hypoconnectivity in schizophrenia: Monkey to human translation of critical pathways for symptom-related functions.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Article
- Dysfunction in primate dorsolateral prefrontal area 46 affects motivation and anxiety.Science (New York, N.Y.) · 2025Article
- Fusion analysis of sMRI-DTI in patients with ulcerative colitis by multimodal CCA + joint ICA and associated neurotransmitter profiles.BMC medicine · 2025Article
- Anatomical mapping of whole-brain monosynaptic inputs to the orbitofrontal cortex.Frontiers in neural circuits · 2025Article
- Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior.Cell reports methods · 2024Article
- Neuronal Mechanisms Underlying Face Recognition in Non-human Primates.The Japanese psychological research · 2024Article
- Unsupervised decomposition of natural monkey behavior into a sequence of motion motifs.Communications biology · 2024Article
- Distinct roles of monkey OFC-subcortical pathways in adaptive behavior.Nature communications · 2024Article
- Stage-dependent role of interhemispheric pathway for motor recovery in primates.Nature communications · 2024Article
- Multiscale chemogenetic dissection of fronto-temporal top-down regulation for object memory in primates.Nature communications · 2024Article
- Implication of regional selectivity of dopamine deficits in impaired suppressing of involuntary movements in Parkinson's disease.Neuroscience and biobehavioral reviews · 2024Review
- The "psychiatric" neuron: the psychic neuron of the cerebral cortex, revisited.Frontiers in human neuroscience · 2024Review
- Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2024Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primate prefrontal cortex (PFC) is situated at the core of higher brain functions via neural circuits such as those linking the caudate nucleus and mediodorsal thalamus. However, the distinctive roles of these prefronto-subcortical pathways remain elusive. Combining in vivo neuronal projection mapping with chemogenetic synaptic silencing, we reversibly dissected key pathways from dorsolateral part of the PFC (dlPFC) to the dorsal caudate (dCD) and lateral mediodorsal thalamus (MDl) individually in single monkeys. We found that silencing the bilateral dlPFC-MDl projections, but not the dlPFC-dCD projections, impaired performance in a spatial working memory task. Conversely, silencing the unilateral dlPFC-dCD projection, but not the unilateral dlPFC-MDl projection, altered preference in a decision-making task. These results revealed dissociable roles of the prefronto-subcortical pathways in working memory and decision-making, representing the technical advantage of imaging-guided pathway-selective chemogenetic manipulation for dissecting neural circuits underlying cognitive functions in primates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.