Evidence map›Paper›PMID 34162522›Full record

ReviewTrends in parasitology2021

Unpacking the intricacies of Rickettsia-vector interactions.

Hanna J Laukaitis, Kevin R Macaluso

Open access · greenAbstract readReview
In one paragraph

Review in Trends in parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Chemical modulation of IMD signaling in the cat flea (Current research in insect science · 2026
    Article
  4. Article
  5. Review
  6. Mechanisms of bacterial host-to-host transmission.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  7. Review
  8. Article
  9. Differential impact of spotted fever groupFrontiers in microbiology · 2025
    Article
  10. Rickettsiosis cases presenting with rash: a case series from an endemic region in Turkey.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025
    Article
  11. Bottom-Up Proteomics Workflow for Studying Multi-organism Systems.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  12. Article
  13. Rocky Mountain Spotted Fever in Mexico: A Call to Action.The American journal of tropical medicine and hygiene · 2024
    Article
  14. Article
  15. Article
  16. Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Cat Flea Coinfection withVector borne and zoonotic diseases (Larchmont, N.Y.) · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hanna J LaukaitisDepartment of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile, AL, USA.
Kevin R MacalusoDepartment of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile, AL, USA. Electronic address: kmacaluso@southalabama.edu.
University of South Alabama · US

Funding

Emerging Flea-Borne Rickettsial Diseases: vector competence and transmission biologyR01AI122672 · NIAID · UNIVERSITY OF SOUTH ALABAMA · PI MACALUSO, KEVIN R. · 2016 to 2025
$4.2M
Molecular basis for spotted fever group Rickettsia vector competence in ticksR01AI077784 · NIAID · UNIVERSITY OF SOUTH ALABAMA · PI MACALUSO, KEVIN R. · 2009 to 2019
$3.5M
NIAID NIH HHS R01 AI077784NIAID NIH HHS R01 AI122672
6 · The paper itself

Abstract

Although Rickettsia species are molecularly detected among a wide range of arthropods, vector competence becomes an imperative aspect of understanding the ecoepidemiology of these vector-borne diseases. The synergy between vector homeostasis and rickettsial invasion, replication, and release initiated within hours (insects) and days (ticks) permits successful transmission of rickettsiae. Uncovering the molecular interplay between rickettsiae and their vectors necessitates examining the multifaceted nature of rickettsial virulence and vector infection tolerance. Here, we highlight the biological differences between tick- and insect-borne rickettsiae and the factors facilitating the incidence of rickettsioses. Untangling the complex relationship between rickettsial genetics, vector biology, and microbial interactions is crucial in understanding the intricate association between rickettsiae and their vectors.

Indexed as

AnimalsArthropod VectorsHost-Pathogen InteractionsRickettsiaRickettsiavectorvector–pathogen interactionsvector transmission

Identifiers

PMID34162522
PMCPMC8344978
OpenAlexW3177047263

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.