ArticleBMC rheumatology2021
Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study.
Article in BMC rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04515589 (Central Aspects of Pain in Rheumatoid Arthritis), which is not on this map. Cited by 7 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Central Aspects of Pain in Rheumatoid Arthritis
Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- CRP Is a Key Indicator of Rheumatoid Arthritis-Associated Vascular Injury and Neurodegeneration.International journal of molecular sciences · 2026Review
- Dynamic psychological vulnerability and adaptation in rheumatoid arthritis: Trajectories, predictors, and interventions.World journal of psychiatry · 2026Review
- Patient and public involvement in musculoskeletal pain research: using mutual learning to improve research quality.Therapeutic advances in musculoskeletal disease · 2026Review
- Validity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis.Pain reports · 2025Article
- The impact of anti-TNF-α therapy on leptin and inflammatory markers in rheumatoid arthritis patients: a case-control study.BMC rheumatology · 2025Article
- Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain.Arthritis research & therapy · 2024Article
- Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network.Rheumatology (Oxford, England) · 2022Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPain and fatigue are persistent problems in people with rheumatoid arthritis. Central sensitisation (CS) may contribute to pain and fatigue, even when treatment has controlled inflammatory disease. This study aims to validate a self-report 8-item questionnaire, the Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA) questionnaire, developed to measure central pain mechanisms in RA, and to predict patient outcomes and response to treatment. A secondary objective is to explore mechanisms linking CS, pain and fatigue in people with RA. METHODS/
designThis is a prospective observational cohort study recruiting 250 adults with active RA in secondary care. The CAP-RA questionnaire, demographic data, medical history, and patient reported outcome measures (PROMs) of traits associated with central sensitization will be collected using validated questionnaires. Quantitative sensory testing modalities of pressure pain detection thresholds, temporal summation and conditioned pain modulation will be indices of central sensitization, and blood markers, swollen joints and ultrasound scans will be indices of inflammation. Primary data collection will be at baseline and 12 weeks. The test-retest reliability of CAP-RA questionnaire will be determined 1 week after the baseline visit. Pain and fatigue data will be collected weekly via text messages for 12 weeks. CAP-RA psychometric properties, and predictive validity for outcomes at 3 months will be evaluated. DISCUSSION: This study will validate a simple self-report questionnaire against psychophysical indices of central sensitization and patient reported outcome measures of traits associated with CS in a population of individuals with active RA. The application of this instrument in the clinical environment could provide a mechanism-based stratification tool to facilitate the provision of targeted therapy to individuals with pain and fatigue in RA, alongside treatments that target joint inflammation.
trial registrationClinicaltrials.gov NCT04515589 . Date of registration 17 August 2020.
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Registered trials
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