Evidence map›Paper›PMID 34162433›Full record

ArticleVeterinary research2021

Damage to intestinal barrier integrity in piglets caused by porcine reproductive and respiratory syndrome virus infection.

Jin Zhao, Shuangxiu Wan, Na Sun, Panpan Sun, Yaogui Sun, Ajab Khan, Jianhua Guo, Xiaozhong Zheng, Kuohai Fan, Wei Yin and 1 more

Open access · goldAbstract read
In one paragraph

Article in Veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Porcine intestinal goblet cells: Guardians of mucosal immunity and barrier function.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Winning the battle of intestinal peace withFrontiers in microbiology · 2025
    Review
  10. Review
  11. Article
  12. Assessing the detection and interaction ofFrontiers in veterinary science · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Jin Zhao *College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.
Shuangxiu Wan *College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.
Na SunCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.
Panpan SunLaboratory Animal Center, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.
Yaogui SunCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.
Ajab KhanCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.
Jianhua GuoDepartment of Veterinary Pathobiology, Schubot Exotic Bird Health Center, Texas A&M University, College Station, TX, 77843, USA.
Xiaozhong ZhengCentre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, EH16 4TJ, UK.
Kuohai FanLaboratory Animal Center, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.
Wei YinCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.
Hongquan LiCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi, China. lhqxzxx@sxau.edu.cn.ORCID http://orcid.org/0000-0002-2030-5587
Shanxi Agricultural University · CNQueen's Medical Centre · GBTexas A&M University · US

Funding

National Key R&D program of China 2017YFD0501500National Natural Science Foundation of China (CN) 31702285Shanxi Province Science Foundation for Youths 201801D211003
6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome (PRRS) induces respiratory disease and reproductive failure accompanied by gastroenteritis-like symptoms. The mechanism of intestinal barrier injury caused by PRRSV infection in piglets has yet to be investigated. An in vivo PRRSV-induced model was established in 30-day-old piglets by the intramuscular injection of 2 mL of 10

Indexed as

Gene ExpressionVirus ReplicationAnimalsGoblet CellsJejunumPorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusSus scrofaSwineTight Junction ProteinsTight Junction ProteinsInflammatory responseIntestinal barrier functionLung-gut axisPorcine reproductive and respiratory syndrome (PRRS)

Identifiers

PMID34162433
PMCPMC8220790
OpenAlexW3176377522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.