Evidence map›Paper›PMID 34162431›Full record

ArticleArchives of public health = Archives belges de sante publique2021

Cause of death for patients with breast cancer: discordance between death certificates and medical files, and impact on survival estimates.

Hava Izci, Tim Tambuyzer, Jessica Vandeven, Jérôme Xicluna, Hans Wildiers, Kevin Punie, Nynke Willers, Eva Oldenburger, Els Van Nieuwenhuysen, Patrick Berteloot and 7 more

Abstract read
In one paragraph

Article in Archives of public health = Archives belges de sante publique, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hava IzciDepartment of Oncology, KU Leuven - University of Leuven, Herestraat 49 box 7003-06, B-3000, Leuven, Belgium. hava.izci@kuleuven.be.ORCID http://orcid.org/0000-0002-3344-0198
Tim TambuyzerBelgian Cancer Registry, Research Department, Brussels, Belgium.
Jessica VandevenBelgian Cancer Registry, Research Department, Brussels, Belgium.
Jérôme XiclunaBelgian Cancer Registry, Research Department, Brussels, Belgium.
Hans WildiersDepartment of Oncology, KU Leuven - University of Leuven, Herestraat 49 box 7003-06, B-3000, Leuven, Belgium.
Kevin PunieDepartment of Oncology, KU Leuven - University of Leuven, Herestraat 49 box 7003-06, B-3000, Leuven, Belgium.
Nynke WillersDepartment of Gynecological Oncology, University Hospitals Leuven, B-3000, Leuven, Belgium.
Eva OldenburgerDepartment of Oncology, KU Leuven - University of Leuven, Herestraat 49 box 7003-06, B-3000, Leuven, Belgium.
Els Van NieuwenhuysenDepartment of Oncology, KU Leuven - University of Leuven, Herestraat 49 box 7003-06, B-3000, Leuven, Belgium.
Patrick BertelootDepartment of Gynecology and Obstetrics, University Hospitals Leuven, B-3000, Leuven, Belgium.
Ann SmeetsDepartment of Oncology, KU Leuven - University of Leuven, Herestraat 49 box 7003-06, B-3000, Leuven, Belgium.
Ines NevelsteenDepartment of Oncology, KU Leuven - University of Leuven, Herestraat 49 box 7003-06, B-3000, Leuven, Belgium.
Anne DeblanderDepartment of Gynecology and Obstetrics, University Hospitals Leuven, B-3000, Leuven, Belgium.
Harlinde De SchutterBelgian Cancer Registry, Research Department, Brussels, Belgium.
Patrick NevenDepartment of Oncology, KU Leuven - University of Leuven, Herestraat 49 box 7003-06, B-3000, Leuven, Belgium.
Geert Silversmit *Belgian Cancer Registry, Research Department, Brussels, Belgium.
Freija Verdoodt *Belgian Cancer Registry, Research Department, Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRegistration and coding of cause of death is prone to error since determining the exact underlying condition leading directly to death is challenging. In this study, causes of death from the death certificates were compared to patients' medical files interpreted by experts at University Hospitals Leuven (UHL), to assess concordance between sources and its impact on cancer survival assessment.

methodsBreast cancer patients treated at UHL (2009-2014) (follow-up until December 31st 2016) were included in this study. Cause of death was obtained from death certificates and expert-reviewed medical files at UHL. Agreement was calculated using Cohen's kappa coefficient. Cause-specific survival (CSS) was calculated using the Kaplan-Meier method and the relative survival probability (RS) using the Ederer II and Pohar Perme method.

resultsA total of 2862 patients, of whom 354 died, were included. We found an agreement of 84.7% (kappa-value of 0.69 (95% C.I.: 0.62-0.77)) between death certificates and medical files. Death certificates had 10.7% false positive and 4.5% false negative rates. However, five-year CSS and RS measures were comparable for both sources.

conclusionFor breast cancer patients included in our study, fair agreement of cause of death was seen between death certificates and medical files with similar CSS and RS estimations.

Indexed as

Breast cancerCause of deathCause-specific survivalDeath certificatesMisclassificationRelative survival

Identifiers

PMID34162431
PMCPMC8220845

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.