Evidence map›Paper›PMID 34162386›Full record

ArticleMicrobial cell factories2021

Universal capability of 3-ketosteroid Δ

Patrycja Wójcik, Michał Glanowski, Agnieszka M Wojtkiewicz, Ali Rohman, Maciej Szaleniec

Open access · goldAbstract read
In one paragraph

Article in Microbial cell factories, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Patrycja WójcikJerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, Niezapominajek 8, 30239, Krakow, Poland.
Michał GlanowskiJerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, Niezapominajek 8, 30239, Krakow, Poland.
Agnieszka M WojtkiewiczJerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, Niezapominajek 8, 30239, Krakow, Poland.
Ali RohmanDepartment of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, 60115, Indonesia.
Maciej SzaleniecJerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences, Niezapominajek 8, 30239, Krakow, Poland. maciej.szaleniec@ikifp.edu.pl.ORCID http://orcid.org/0000-0002-7650-9263
Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences · PLUniversity of Groningen · NL

Funding

Narodowe Centrum Badań i Rozwoju POWR.03.02.00-00-I013/16Narodowe Centrum Nauki 2016/21/B/ST4/03798Narodowe Centrum Nauki 2018/02/X/ST4/01963
6 · The paper itself

Abstract

background3-Ketosteroid Δ

resultsMolecular dynamics simulations on KSTD1 from Rhodococcus erythropolis indicated no difference in ΔG

conclusionsWe confirmed the existence of AcmB preference for a substrate with an undegraded isooctyl chain. However, we showed that KSTD1 which was reported to be inactive with such substrates can catalyze the reaction if the solubility problem is addressed.

Indexed as

2-Hydroxypropyl-beta-cyclodextrinBacterial ProteinsBetaproteobacteriaCatalysisCholestenonesCloning, MolecularDNA, BacterialIsoenzymesKetosteroidsKineticsMolecular Dynamics SimulationOxidoreductasesRecombinant ProteinsRhodococcusSpiro CompoundsSteroids2-Hydroxypropyl-beta-cyclodextrin3-oxosteroid delta(1) dehydrogenaseBacterial Proteinscholest-4-en-3-oneCholestenonesdiosgenoneDNA, BacterialIsoenzymesKetosteroidsOxidoreductasesRecombinant ProteinsSpiro CompoundsSteroidsTriterpenes1,2-dehydrogenation3-ketosteroid dehydrogenase3-ketosteroidsCholest-4-en-3-oneCholest-4-en-3-one Δ1-dehydrogenaseCholesterol metabolismDiosgenoneKSTDΔ1-dehydrogenation

Identifiers

PMID34162386
PMCPMC8220720
OpenAlexW3139492444

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.