Evidence map›Paper›PMID 34162352›Full record

ArticleBMC neurology2021

Efficacy and safety of pulsed radiofrequency modulation of thoracic dorsal root ganglion or intercostal nerve on postherpetic neuralgia in aged patients: a retrospective study.

Xuehua Huang, Yanfeng Ma, Weimin Wang, Yunxiu Guo, Bo Xu, Ke Ma

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07367152 (Predictors of Treatment Success After Intercostal Nerve Radiofrequency for Intercostal Neuralgia), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07367152 completednot on this map

Predictors of Treatment Success After Intercostal Nerve Radiofrequency for Intercostal Neuralgia: A Retrospective Cohort Study

TypeobservationalSponsorMersin UniversityRan2018 to 2025Enrolled60ConditionsIntercostal Neuralgia, Postherpetic Neuralgia ( PHN ), Thoracic Neuropathic PainArmsIntercostal Nerve Conventional Radiofrequency Ablation (CRF), Intercostal Nerve Pulsed Radiofrequency (PRF)
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  9. Impact of Pulsed Radiotherapy on Pain and Quality of Life in Elderly Postherpetic Neuralgia Patients.Medical science monitor : international medical journal of experimental and clinical research · 2025
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  10. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xuehua Huang *Department of Pain, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China.
Yanfeng Ma *Department of Pain, The Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
Weimin Wang *Department of Pain, The Fourth People's Hospital, Yancheng, Jiangsu, PR China.
Yunxiu Guo *Department of Anesthesiology, Xinhua Hospital Chongming Branch, Shanghai, PR China.
Bo XuDepartment of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China. xubo@xinhuamed.com.cn.
Ke MaDepartment of Pain, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China. make@xinhuamed.com.cn.
XinHua Hospital · CNShanghai University of Traditional Chinese Medicine · CNThe Fourth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostherpetic neuralgia (PHN) is common in elderly patients and can be alleviated by pulsed radiofrequency (PRF). However, PRF treatments display different efficacy on different nerves. The purpose of this study was to evaluate the efficacy and safety of ultrasound-guided PRF modulation on thoracic dorsal root ganglion (DRG) or intercostal nerve (ICN) for PHN in aged patients and to provide a theoretical basis for clinical treatment.

methodsWe classified aged patients into two groups, DRG group and ICN group, based on the needle tip position. Visual analogue scale (VAS) and concise health status questionnaire (Short-form 36 health/survey questionnaire, SF-36) were used to evaluate the pain intensity and the life quality of the patients before and 2, 4 and 12 weeks after the PRF treatments. We also recorded the adverse reactions during the treatments.

resultsAfter the PRF treatment, the scores of VAS and SF-36 (assessing general health perception, social function, emotional role, mental health, and pain) improved significantly in both groups (P < 0.05). The mean VAS score in the DRG group was significantly lower than that in the ICN group 2 weeks after treatment, and remained for 12 weeks. The SF-36 scores in the DRG group were significantly higher than those in the ICN group (P < 0.05). We found a similar incidence of adverse reactions between the two groups (P > 0.05).

conclusionsPRF therapy is safe and effective for elderly patients with postherpetic neuralgia. However, PRF treatment in dorsal root ganglion is superior to that in intercostal nerve with improving VAS and SF-36 scores to a greater extent in older patients.

trial registrationChiCTR2100044176 .

Indexed as

Pulsed Radiofrequency TreatmentAgedEmotionsFemaleGanglia, SpinalHumansIntercostal NervesMaleMental HealthNeuralgia, PostherpeticPain ManagementRetrospective StudiesTreatment OutcomeDorsal root ganglionIntercostal nervePostherpetic neuralgiaPulsed radiofrequenciesThe aged patients

Identifiers

PMID34162352
PMCPMC8223296
OpenAlexW3173466820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.