Evidence map›Paper›PMID 34162308›Full record

ArticleEmerging microbes & infections2021

The liver X receptor agonist LXR 623 restricts flavivirus replication.

Luwanika Mlera, Danielle K Offerdahl, David W Dorward, Aaron Carmody, Abhilash I Chiramel, Sonja M Best, Marshall E Bloom

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luwanika MleraBiology of Vector-Borne Viruses Section, Laboratory of Virology, NIAID/NIH, Hamilton, MT, USA.
Danielle K OfferdahlBiology of Vector-Borne Viruses Section, Laboratory of Virology, NIAID/NIH, Hamilton, MT, USA.ORCID https://orcid.org/0000-0002-0736-1664
David W DorwardMicroscopy Unit, Research Technologies Branch, NIAID/NIH, Hamilton, MT, USA.
Aaron CarmodyResearch Technologies Branch, NIAID/NIH, Hamilton, MT, USA.
Abhilash I ChiramelInnate Immunity and Pathogenesis Section, Laboratory of Virology, NIAID/NIH, Hamilton, MT, USA.
Sonja M BestInnate Immunity and Pathogenesis Section, Laboratory of Virology, NIAID/NIH, Hamilton, MT, USA.
Marshall E BloomBiology of Vector-Borne Viruses Section, Laboratory of Virology, NIAID/NIH, Hamilton, MT, USA.

Funding

Infectious Diseases Research Technologies Core - RMLZICAI001052 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2009 to 2025
$133.3M
Virus-Host Interactions: Induction and Evasion of Host Innate ImmunityZIAAI001125 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BEST, SONJA · 2010 to 2025
$28.1M
Pathogenesis of Tick-Borne Flavivirus InfectionsZIAAI000940 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BLOOM, MARSHALL ELLIOTT · 2009 to 2025
$19.6M
6 · The paper itself

Abstract

The vector-borne flaviviruses (VBFVs) are well known for causing great misery and death in humans worldwide. The VBFVs include those transmitted by mosquitos, such as Zika virus (ZIKV), dengue virus; and those transmitted by ticks including the tick-borne flavivirus serocomplex and Powassan virus (POWV). Two of our recent reports showed that intracranial POWV infection in the reservoir host,

Indexed as

Antiviral AgentsCell Line, TumorCell ProliferationCytokinesCytopathogenic Effect, ViralCytoplasmic VesiclesEncephalitis Viruses, Tick-BorneEndoplasmic ReticulumHumansIndazolesLiver X ReceptorsVirus ReplicationZika Virus2-(2-chloro-4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazoleAntiviral AgentsCytokinesIndazolesLiver X ReceptorsFlavivirusliver X receptorLXR 623Powassan virusvirus restrictionZika virus

Identifiers

PMID34162308
PMCPMC8259867
OpenAlexW3174784045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.