Evidence map›Paper›PMID 34162286›Full record

ReviewChronobiology international2023

Circadian rhythms in cardiac metabolic flexibility.

Martin E Young, Mary N Latimer

Open access · greenAbstract readReview
In one paragraph

Review in Chronobiology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Martin E YoungDivision of Cardiovascular Disease, Department of Medicine, University of Alabama, Birmingham, Alabama, USA.ORCID 0000-0001-8360-5029
Mary N LatimerDivision of Cardiovascular Disease, Department of Medicine, University of Alabama, Birmingham, Alabama, USA.
University of Alabama at Birmingham · US

Funding

Metabolic Rhythm Alterations as a Cause for Obesity CardiomyopathyR01HL149159 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YOUNG, MARTIN E · 2019 to 2022
$1.9M
Disruption of the Clock O-GlcNAc axis in diabetic cardiomyopathyR01HL122975 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHATHAM, JOHN C, YOUNG, MARTIN E · 2015 to 2018
$1.6M
Circadian Regulation of Myocardial Insulin SignalingR01HL123574 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YOUNG, MARTIN E · 2014 to 2017
$1.5M
Basic and Translational Science in Heart FailureT32HL129948 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YOUNG, MARTIN E · 2017 to 2021
$1.4M
Circadian Regulation of mTOR Signaling in the Failing HeartF32HL154531 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LATIMER, MARY NESLUND · 2020 to 2020
$65k
NHLBI NIH HHS F32 HL154531NHLBI NIH HHS R01 HL122975NHLBI NIH HHS R01 HL123574NHLBI NIH HHS R01 HL149159NHLBI NIH HHS T32 HL129948
6 · The paper itself

Abstract

Numerous aspects of cardiovascular physiology (e.g., heart rate, blood pressure) and pathology (e.g., myocardial infarction and sudden cardiac death) exhibit time-of-day-dependency. In association with day-night differences in energetic demand and substrate availability, the healthy heart displays remarkable metabolic flexibility through temporal partitioning of the metabolic fate of common substrates (glucose, lipid, amino acids). The purpose of this review is to highlight the contribution that circadian clocks provide toward 24-hr fluctuations in cardiac metabolism and to discuss whether attenuation and/or augmentation of these metabolic rhythms through adjustment of nutrient intake timing impacts cardiovascular disease development.

Indexed as

Circadian ClocksMyocardial InfarctionBlood PressureCircadian RhythmHeartHumansCircadianheartmetabolismnutrients

Identifiers

PMID34162286
PMCPMC8695643
OpenAlexW3175998074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.