ArticleCirculation research2021
Unveiling Complexity and Multipotentiality of Early Heart Fields.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 56 papers.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 96 citations in OpenAlex.
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- Coordination of cardiogenesis in vivo and in vitro.Nature reviews. Molecular cell biology · 2026Review
- Understanding normal cardiac morphogenesis and its disruptions: a journey through pathways.Frontiers in genetics · 2026Review
- 3D spatial organization of heterogeneous nkx2.5+ progenitors in the zebrafish heart field pre-patterns cardiovascular development.Nature communications · 2025Article
- The pericardium forms as a distinct structure during heart formation.Nature communications · 2025Article
- Myocardium and endocardium of the early mammalian heart tube arise from independent multipotent lineages specified at the primitive streak.Developmental cell · 2025Article
- Integration of single-cell and spatial transcriptomics by SEU-TCA reveals the spatial origin of early cardiac progenitors.Genome biology · 2025Article
- Early coordination of cell migration and cardiac fate determination during mammalian gastrulation.The EMBO journal · 2025Article
- A retinoic acid:YAP1 signaling axis controls atrial lineage commitment.Cell reports · 2025Article
- A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development.Cell reports · 2025Article
- Intronic RNAscope probes enable precise identification of cardiomyocyte nuclei and cell cycle activity.Communications biology · 2025Article
- Global, regional, and national burden of congenital heart disease, 1990-2021: a systematic analysis for the global burden of disease study 2021.European journal of pediatrics · 2025Article
- Mesodermal fibronectin controls cell shape, polarity, and mechanotransduction in the second heart field during cardiac outflow tract development.Developmental cell · 2025Article
- Decoding congenital heart disease: a multi-omic framework for cardiac lineage and regulatory dysfunction.Frontiers in cell and developmental biology · 2025Review
- Gastruloids are competent to specify both cardiac and skeletal muscle lineages.Nature communications · 2024Article
Corrections and comments
- Commented on by
- Erratum issued
- Erratum issued
Authors and funding
8 authors at 2 institutions in 2 countries.
Qingquan Zhang *Medicine, Division of Cardiology (Q.Z., D.C., F.Z., P.C., S.M.E., J.B., N.C.C.).
Daniel Carlin *Medicine, Division of Cardiology (Q.Z., D.C., F.Z., P.C., S.M.E., J.B., N.C.C.).
Fugui ZhuMedicine, Division of Cardiology (Q.Z., D.C., F.Z., P.C., S.M.E., J.B., N.C.C.).
Paola CattaneoMedicine, Division of Cardiology (Q.Z., D.C., F.Z., P.C., S.M.E., J.B., N.C.C.).
Trey IdekerMedicine, Division of Genetics (T.I.).
Sylvia M EvansMedicine, Division of Cardiology (Q.Z., D.C., F.Z., P.C., S.M.E., J.B., N.C.C.).
Joshua BloomekatzMedicine, Division of Cardiology (Q.Z., D.C., F.Z., P.C., S.M.E., J.B., N.C.C.).
Neil C ChiMedicine, Division of Cardiology (Q.Z., D.C., F.Z., P.C., S.M.E., J.B., N.C.C.).
United States Nuclear Regulatory Commission · USNational Institute of Genomic Medicine · MX
Funding
TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3MREGULATORY GENOMIC STUDIES IN A COHORT OF IPS CELL DERIVED CARDIOMYOCYTESU01HL107442 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EVANS, SYLVIA M, FRAZER, KELLY A · 2011 to 2016
$9.8MRenewing the heart: cardiomyocyte cell cycle regulationR35HL144984 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EVANS, SYLVIA M · 2019 to 2025
$6.1MDevelopmental Regulatory Genomics of Human Cardiovascular LineagesUM1HL128773 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, EVANS, SYLVIA M · 2015 to 2019
$3.8MFine-scale Spatiotemporal Mapping of Cellular Regulatory Networks Directing Heart DevelopmentR01HD103278 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C · 2020 to 2024
$3.1MNHLBI NIH HHS R35 HL144984NHLBI NIH HHS U01 HL107442NHLBI NIH HHS UM1 HL128773NICHD NIH HHS R01 HD103278NIGMS NIH HHS P41 GM103504
Abstract
[Figure: see text].
Indexed as
Cell LineageAnimalsCell DifferentiationFetal HeartMesodermMiceMouse Embryonic Stem CellsMyocytes, CardiacRNA-SeqSingle-Cell AnalysisTranscriptomecongenital heart defectsembryonic developmentgenomicsmyocardiumstem cells
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.