ArticleDementia and geriatric cognitive disorders2021
Intrusion Errors and Progression of Cognitive Deficits in Older Adults with Mild Cognitive Impairment and PreMCI States.
Article in Dementia and geriatric cognitive disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Combining plasma biomarkers and cognitive challenge tests enhances prediction of functional trajectories of decline among older adults with cognitive impairment.Journal of Alzheimer's disease : JAD · 2026Article
- Cognitive dysfunction in women with theJournal of Alzheimer's disease : JAD · 2026Article
- Development and comparison of alternate forms of the Loewenstein-Acevedo Scales for Semantic Interference and Learning-Digital Version (LASSI-D) in older participants with amnestic mild cognitive impairment and normal cognition.Journal of Alzheimer's disease : JAD · 2025Article
- Validity of the Loewenstein-Acevedo Scales of Semantic Interference and Learning (LASSI-L) for Mexican Subjects with Mild and Moderate Cognitive Impairments.Geriatrics (Basel, Switzerland) · 2025Article
- Detecting Cognitive Impairment in African American Older Adults Using the LASSI-L and Plasma P-TauAdvances in Alzheimer's disease · 2025Article
- Failure to recover from proactive semantic interference predicts trajectory of decline in everyday function among older adults with amnestic mild cognitive impairment.International psychogeriatrics · 2025Article
- Digital Migration of the Loewenstein Acevedo Scales for Semantic Interference and Learning (LASSI-L): Development and Validation Study in Older Participants.JMIR mental health · 2025Article
- Hippocampal Synaptic Plasticity: Integrating Memory and Anxiety Impairments in the Early Stages of Alzheimer's Disease.Current topics in behavioral neurosciences · 2025Review
- Article
- Unraveling progressive verbal memory deficits in Huntington's disease: insights from the LASSI-L.Frontiers in neurology · 2025Article
- Semantic intrusion errors differentiate between amnestic MCI who are plasma p-tauFrontiers in neurology · 2025Article
- The computerized LASSI-BC Test versus the Standard LASSI-L Paper-and-Pencil Version in Community-Based-Samples.Advances in Alzheimer's disease · 2024Article
- The Association Between Plasma Amyloid-β 42/40 and Percentage of Semantic Intrusion Errors in Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2024Article
- Different aspects of failing to recover from proactive semantic interference predicts rate of progression from amnestic mild cognitive impairment to dementia.Frontiers in aging neuroscience · 2024Article
- A Novel Computerized Cognitive Test for the Detection of Mild Cognitive Impairment and Its Association with Neurodegeneration in Alzheimer's Disease Prone Brain Regions.Advances in Alzheimer's disease · 2023Article
- A review of novel Cognitive Challenge Tests for the assessment of preclinical Alzheimer's disease.Neuropsychology · 2023Review
- Increased regional white matter hyperintensity volume in objectively-defined subtle cognitive decline and mild cognitive impairment.Neurobiology of aging · 2022Article
- Persistent Failure to Recover from Proactive Semantic Interference on the Cognitive Stress Test Differentiates Between Amnestic Mild Cognitive Impairment, Pre-Mild Cognitive Impairment, and Cognitively Unimpaired Older Adults.Journal of Alzheimer's disease : JAD · 2022Article
- Salient Cognitive Paradigms to Assess Preclinical Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Changes in LASSI-L performance over time among older adults with amnestic MCI and amyloid positivity: A preliminary study.Journal of psychiatric research · 2021Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
introductionAmong persons with amnestic mild cognitive impairment (aMCI), intrusion errors on subscales that measure proactive semantic interference (PSI) may be among the earliest behavioral markers of elevated Alzheimer's disease brain pathology. While there has been considerable cross-sectional work in the area, it is presently unknown whether semantic intrusion errors are predictive of progression of cognitive impairment in aMCI or PreMCI (not cognitively normal but not meeting full criteria for MCI).
methodsThis study examined the extent to which the percentage of semantic intrusion errors (PIE) based on total responses on a novel cognitive stress test, the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L), could predict clinical/cognitive outcomes over an average 26-month period in older adults initially diagnosed with aMCI, PreMCI, and normal cognition.
resultsOn the LASSI-L subscale sensitive to PSI, a PIE cut point of 44% intrusion errors distinguished between those at-risk individuals with PreMCI who progressed to MCI over time compared to individuals with PreMCI who reverted to normal on longitudinal follow-up. Importantly, PIE was able to accurately predict 83.3% of aMCI individuals who later progressed to dementia. DISCUSSION: These preliminary findings indicate that PIE on LASSI-L subscales that measure PSI may be a useful predictor of clinical progression overtime in at-risk older adults.
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