SynthesisNeuroImage. Clinical2021
The functional neural architecture of dysfunctional reward processing in autism.
Synthesis in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Distinct neurobiological alterations during hedonic experience of rewards in attention deficit hyperactivity disorder and autism spectrum disorder: Multimodal evidence from neuroimaging meta-analyses.Molecular psychiatry · 2026Pooled it
- Shared and Specific Neural Correlates of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder: A Meta-Analysis of 243 Task-Based Functional MRI Studies.The American journal of psychiatry · 2024Pooled it
- Meta-analytic connectivity modelling of functional magnetic resonance imaging studies in autism spectrum disorders.Brain imaging and behavior · 2023Pooled it
- Functional Connectivity During Social Reward Processing in Autistic and Neurotypical Adolescents.Brain and behavior · 2026Article
- Leveraging AI-Driven Neuroimaging Biomarkers for Early Detection and Social Function Prediction in Autism Spectrum Disorders: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Structure of subcortico-cortical tracts in middle-aged and older adults with autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A reward self-bias leads to more optimal foraging for ourselves than others.Scientific reports · 2024Article
- Differently different?: A commentary on the emerging social cognitive neuroscience of female autism.Biology of sex differences · 2024Review
- Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders.Molecular psychiatry · 2024Article
- Neurochemical differences in core regions of the autistic brain: a multivoxelScientific reports · 2024Article
- Developmental Disruptions of the Dorsal Striatum in Autism Spectrum Disorder.Biological psychiatry · 2024Review
- Exploring the most discriminative brain structural abnormalities in ASD with multi-stage progressive feature refinement approach.Frontiers in psychiatry · 2024Article
- Processing of social and monetary rewards in autism spectrum disorders.The British journal of psychiatry : the journal of mental science · 2023Article
- Molecular Abnormalities in BTBR Mice and Their Relevance to Schizophrenia and Autism Spectrum Disorders: An Overview of Transcriptomic and Proteomic Studies.Biomedicines · 2023Article
- A novel technique for delineating the effect of variation in the learning rate on the neural correlates of reward prediction errors in model-based fMRI.Frontiers in psychology · 2023Article
- Neurobiological insights into twice-exceptionality: Circuits, cells, and molecules.Neurobiology of learning and memory · 2022Article
- Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish.Molecular autism · 2022Article
- Mesolimbic Neurobehavioral Mechanisms of Reward Motivation in Anorexia Nervosa: A Multimodal Imaging Study.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Functional imaging studies have found differential neural activation patterns during reward-paradigms in patients with autism spectrum disorder (ASD) compared to neurotypical controls. However, publications report conflicting results on the directionality and location of these aberrant activations. We here quantitatively summarized relevant fMRI papers in the field using the anatomical likelihood estimation (ALE) algorithm. Patients with ASD consistently showed hypoactivations in the striatum across studies, mainly in the right putamen and accumbens. These regions are functionally involved in the processing of rewards and are enrolled in extensive neural networks involving limbic, cortical, thalamic and mesencephalic regions. The striatal hypo-activations found in our ALE meta-analysis, which pooled over contrasts derived from the included studies on reward-processing in ASD, highlight the role of the striatum as a key neural correlate of impaired reward processing in autism. These changes were present for studies using social and non-social stimuli alike. The involvement of these regions in extensive networks associated with the processing of both positive and negative emotion alike might hint at broader impairments of emotion processing in the disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.