Evidence map›Paper›PMID 34161816›Full record

ArticleActa tropica2021

Use of partial N-gene sequences as a tool to monitor progress on rabies control and elimination efforts in Ethiopia.

Laura Binkley, Asefa Deressa, Mang Shi, Manuel Jara, Luis E Escobar, Mathew R Mauldin, Audrey Matheny, Jeanette O'Quin, Emily G Pieracci, Chantal Kling and 9 more

Abstract read
In one paragraph

Article in Acta tropica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Laura BinkleyOhio State University Global One Health Initiative, Columbus, OH, USA.
Asefa DeressaEthiopian Public Health Institute, Gulele Sub City, Addis Ababa, Ethiopia.
Mang ShiCentre for Infection and Immunity Studies, School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Manuel JaraDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Luis E EscobarDepartment of Fish and Wildlife Conservation, Virginia Polytechnic Institute and State University, Blacksburg, VA 24601, USA.
Mathew R MauldinCenters for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA.
Audrey MathenyCenters for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA.
Jeanette O'QuinOhio State University Global One Health Initiative, Columbus, OH, USA.
Emily G PieracciCenters for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA.
Chantal KlingCenters for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA.
Claire HartlogeCenters for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA.
Getnet YimerOhio State University Global One Health Initiative, Columbus, OH, USA.
Ebba AbateEthiopian Public Health Institute, Gulele Sub City, Addis Ababa, Ethiopia.
Wondwossen GebreyesOhio State University Global One Health Initiative, Columbus, OH, USA.
Mary ReynoldsCenters for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA.
Ermias BelayCenters for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA.
Miriam ShiferawCenters for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA.
Yoshinori NakazawaCenters for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA.
Andres Velasco-VillaCenters for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA. Electronic address: dly3@cdc.gov.

Funding

CGH CDC HHS U2G GH001752
6 · The paper itself

Abstract

Ethiopia is one of the African countries most affected by rabies. A coarse catalog of rabies viruses (RABV) was created as a benchmark to assess the impact of control and elimination activities. We evaluated a 726 bp amplicon at the end of the N-gene to infer viral lineages in circulation using maximum likelihood and Bayesian methods for phylogenetic reconstruction. We sequenced 228 brain samples from wild and domestic animals collected in five Ethiopian regions during 2010-2017. Results identified co-circulating RABV lineages that are causing recurrent spillover infections into wildlife and domestic animals. We found no evidence of importation of RABVs from other African countries or vaccine-induced cases in the area studied. A divergent RABV lineage might be involved in an independent rabies cycle in jackals. This investigation provides a feasible approach to assess rabies control and elimination efforts in resource-limited countries.

Indexed as

RabiesRabies virusAnimalsBayes TheoremEthiopiaPhylogenyCo-circulating lineagesDog rabiesMonitoring eliminationResource-limited countries

Identifiers

PMID34161816
PMCPMC8652542

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.