ArticleCell reports2021
Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- The Interplay of Microtubules with Mitochondria-ER Contact Sites (MERCs) in Glioblastoma.Biomolecules · 2022Pooled it
- Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells.International forum of allergy & rhinology · 2026Article
- Loss of TMEM65 in mice causes mitochondrial disease mediated by mitochondrial CaNature communications · 2026Article
- Mitochondrial energetic failure underlies FLVCR1-related sensory neuropathy.Communications biology · 2026Article
- Targeting ion channel dysregulation in tumors: emerging therapeutic opportunities.Trends in pharmacological sciences · 2026Review
- Placental mitochondrial calcium uniporter modulates offspring susceptibility to metabolic dysfunction.Molecular metabolism · 2025Article
- Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function.European journal of heart failure · 2025Review
- Mitochondrial CaJournal of cellular physiology · 2025Review
- Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer's disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance.Alzheimer's research & therapy · 2025Article
- Orai channel pharmacological manipulation reduces metabolic flexibility in cardiac fibroblasts.American journal of physiology. Cell physiology · 2025Article
- The roles of mitochondria in global and local intracellular calcium signalling.Nature reviews. Molecular cell biology · 2025Review
- Mutated sigma-1R disrupts cell homeostasis in dHMN patient cells.Cellular and molecular life sciences : CMLS · 2025Article
- Mitochondrial calcium uniporter as biomarker and therapeutic target for breast cancer: Prognostication, immune microenvironment, epigenetic regulation and precision medicine.Journal of advanced research · 2025Article
- Discovery of benzethonium chloride as a potent STAT3 inhibitor for the treatment of HNSCC.Frontiers in pharmacology · 2025Article
- Knockdown of hepatic mitochondrial calcium uniporter mitigates MASH and fibrosis in mice.Cell & bioscience · 2024Article
- Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments.PLoS biology · 2024Article
- Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium.Cancer discovery · 2024Article
- Myocardial transcriptomic analysis of diabetic patients with aortic stenosis: key role for mitochondrial calcium signaling.Cardiovascular diabetology · 2024Article
- A PET-Surrogate Signature for the Interrogation of the Metabolic Status of Breast Cancers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Mitochondrial CaScientific reports · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Agnese De MarioDepartment of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
Anna TosattoDepartment of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
Julia Marie HillDepartment of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, London WC1E 6BT, UK.
Janos Kriston-ViziBioinformatics Image Core (BIONIC), MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Robin KettelerCell Signalling and Autophagy Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Denis Vecellio ReaneDepartment of Biomedical Sciences, University of Padua, 35131 Padua, Italy.
Gino CortopassiDepartment of Molecular Bioscience, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Gyorgy SzabadkaiDepartment of Biomedical Sciences, University of Padua, 35131 Padua, Italy; Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, London WC1E 6BT, UK; Francis Crick Institute, London WC1E 6BT, UK.
Rosario RizzutoDepartment of Biomedical Sciences, University of Padua, 35131 Padua, Italy; Myology Center (CIR-Myo), University of Padua, 35131 Padua, Italy. Electronic address: rosario.rizzuto@unipd.it.
Cristina MammucariDepartment of Biomedical Sciences, University of Padua, 35131 Padua, Italy; Myology Center (CIR-Myo), University of Padua, 35131 Padua, Italy. Electronic address: cristina.mammucari@unipd.it.
University of Padua · ITMRC Laboratory for Molecular Cell Biology · GBUniversity College London · GBUniversity of California, Davis · US
Funding
Medical Research Council MC_EX_G0800785Medical Research Council MC_U12266B
Abstract
The mitochondrial calcium uniporter (MCU), the highly selective channel responsible for mitochondrial Ca
Indexed as
United States Food and Drug AdministrationAnimalsApoptosisBenzethoniumBreast NeoplasmsCalciumCalcium ChannelsCell Line, TumorCell MovementCell ProliferationCytoprotectionDuloxetine HydrochlorideEnergy MetabolismFemaleHigh-Throughput Screening AssaysHomeostasisamorolfineBenzethoniumCalciumCalcium ChannelsDuloxetine Hydrochloridemitochondrial calcium uniporterMorpholinesReactive Oxygen SpeciesamorolfinebenzethoniumFDA-approved drugshigh-throughput screeningMCUmitochondrial Ca(2+) uptakemitochondrial calcium uniporterskeletal muscle hypertrophytriple-negative breast cancer
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.