Evidence map›Paper›PMID 34161746›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Impact of age and cyclooxygenase inhibition on the hemodynamic response to acute cognitive challenges.

Andrew G Pearson, Kathleen B Miller, Adam T Corkery, Nicole A Eisenmann, Anna J Howery, Alexandra E Carl, Marlowe W Eldridge, Jill N Barnes

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Andrew G PearsonBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0002-3908-936X
Kathleen B MillerBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0003-2878-3978
Adam T CorkeryBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin.
Nicole A EisenmannBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin.
Anna J HoweryBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin.
Alexandra E CarlBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin.
Marlowe W EldridgeDivision of Critical Care, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Jill N BarnesBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0001-6317-4153
University of Wisconsin–Madison · US

Funding

Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6M
Cerebral blood flow, connectivity and cognition: the effect of age and exerciseR00HL118154 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BARNES, JILL NICOLE · 2015 to 2017
$735k
Cerebral blood flow, connectivity and cognition: the effect of age and exerciseK99HL118154 · NHLBI · MAYO CLINIC ROCHESTER · PI BARNES, JILL NICOLE · 2014 to 2015
$180k
NHLBI NIH HHS K99 HL118154NHLBI NIH HHS R00 HL118154NHLBI NIH HHS T32 HL007936
6 · The paper itself

Abstract

Structural and functional changes in the cerebral vasculature occur with advancing age, which may lead to impaired neurovascular coupling (NVC) and cognitive decline. Cyclooxygenase (COX) inhibition abolishes age-related differences in cerebrovascular reactivity, but it is unclear if COX inhibition impacts NVC. The purpose of this study was to examine the influence of aging on NVC before and after COX inhibition. Twenty-three young (age = 25 ± 4 yr) and 21 older (age = 64 ± 5 yr) adults completed two levels of difficulty of the Stroop and

Indexed as

CognitionAdolescentAdultAgedAge FactorsCerebrovascular CirculationCognitive AgingCyclooxygenase InhibitorsExecutive FunctionFemaleHemodynamicsHumansIndomethacinMaleMemory, Short-TermMiddle AgedCyclooxygenase InhibitorsIndomethacinarterial stiffnessblood flowblood pressureexecutive functionworking memory

Identifiers

PMID34161746
PMCPMC8409912
OpenAlexW3173618906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.