SynthesisJournal of thrombosis and haemostasis : JTH2021
D-dimer to rule out venous thromboembolism during pregnancy: A systematic review and meta-analysis.
Synthesis in Journal of thrombosis and haemostasis : JTH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- D-dimer to rule out venous thromboembolism during pregnancy: A systematic review and meta-analysis.Journal of thrombosis and haemostasis : JTH · 2021Pooled it
- High-risk pulmonary embolism in the first trimester of pregnancy: Successful thrombolysis with tenecteplase.Radiology case reports · 2026Article
- Pregnancy Complicated by Hereditary Antithrombin Deficiency: A Case Study and Insights From the Literature.Clinical case reports · 2026Article
- D-Dimer levels during pregnancy and postpartum: non-applicability of regularly used cut-offs for diagnosis of suspected pulmonary embolism.Archives of gynecology and obstetrics · 2026Article
- Genetic risk assessment of pregnancy-associated venous thromboembolism: dual utility of maternal peripheral blood in NIPT and VTE evaluation.BMC pregnancy and childbirth · 2026Article
- Antenatal Pulmonary Embolism Diagnostics in Pregnant Patients with SARS-CoV-2 Infection in Community Hospitals.TH open : companion journal to thrombosis and haemostasis · 2026Article
- Machine learning prediction of postoperative pulmonary embolism: a multicenter external validation study highlighting inflammatory response and intraoperative hemodynamics.Frontiers in cardiovascular medicine · 2026Article
- Strategies to Reduce Advanced Imaging in Antenatal Pulmonary Embolism Diagnostics.JAMA network open · 2025Article
- Construction and evaluation of a risk prediction model for postoperative deep vein thrombosis in gynecological patients.The journal of obstetrics and gynaecology research · 2025Article
- Diagnosing Pulmonary Embolism During Pregnancy.Chest · 2025Review
- Predictive Value of Centered Clinical Asymmetric Lower Limb Edema in Diagnosing Deep Vein Thrombosis in Puerperium.Journal of clinical medicine · 2025Article
- Exploring Biomarkers to Predict Thrombogenic Risk in Pregnancy.Journal of clinical medicine · 2025Article
- The clinical significance of D-dimer concentrations predicting the risk of venous thromboembolism in patients with hyperemesis gravidarum.Revista da Associacao Medica Brasileira (1992) · 2025Article
- An Increased Plasma D-Dimer Levels During Different Stages of Normal and Complicated Pregnancies Among Women in Bisha, Saudi Arabia.Journal of blood medicine · 2025Article
- Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches.International journal of oral science · 2024Review
- Pregnancy-Related Thromboembolism-Current Challenges at the Emergency Department.Journal of personalized medicine · 2024Review
- Diagnostic value of D-dimer to fibrinogen ratio for pulmonary embolism in postpartum women.BMC pregnancy and childbirth · 2024Article
- High and intermediate risk pulmonary embolism in the ICU.Intensive care medicine · 2024Review
- Clinical Maternal and Neonatal Features in COVID-19 Infected Pregnancies in Tianjin, China.International journal of general medicine · 2024Article
- Trimester-specific reference intervals and profile of coagulation parameters for Chinese pregnant women with diverse demographics and obstetric history: a cross-sectional study.BMC pregnancy and childbirth · 2023Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe usefulness of D-dimer measurement to rule out venous thromboembolism (VTE) during pregnancy is debated.
objectivesWe performed a systematic review and meta-analysis to investigate the safety of D-dimer to rule out acute VTE in pregnant women with suspected pulmonary embolism and/or deep vein thrombosis.
methodsTwo reviewers independently identified studies through PubMed and Embase until June 2021, week 1. We supplemented our search by manually reviewing reference lists of all retrieved articles, clinicalTrials.gov, and reference literature. Prospective or retrospective studies in which a formal diagnostic algorithm was used to evaluate the ability of D-dimer to rule out VTE during pregnancy were eligible.
resultsWe identified 665 references through systematic database and additional search strategies; 45 studies were retrieved in full, of which four were included, after applying exclusion criteria. Three studies were prospective, and one had a retrospective design. The 3-month thromboembolic rate in pregnant women left untreated after a negative D-dimer was 1/312 (0.32%; 95% CI, 0.06-1.83). The pooled estimate values were 99.5% for sensitivity (95% CI, 95.0-100.0; I², 0%) and 100% for negative predictive value (95% CI, 99.19-100.0; I², 0%). The prevalence of VTE and the yield of D-dimer were 7.4% (95% CI, 3.8-12; I², 83%) and 34.2% (95% CI, 15.9-55.23; I², 89%) respectively.
conclusionOur results suggest that D-dimer allows to safely rule out VTE in pregnant women with suspected VTE and a disease prevalence consistent with a low/intermediate or unlikely pretest probability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.